{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:34:07Z","timestamp":1777581247949,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To examine changes of the choroidal morphology in patients with diabetic macular edema (DME) before and after local treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study was on 20 eyes with DME, observed for more than 24\u2009months. All patients underwent laser photocoagulation (Laser), sub-tenon triamcinolone acetonide injection (TA), or intravitreal aflibercept injection (IVA). Central macular and choroidal thicknesses (CMT\/CCT), and choroidal vascular structures consisting of the total choroidal area (TCA), luminal area (LA), and stromal area (SA) were measured by a binarization method. The ratios of LA in TCA were eventually determined as the L\/C ratio in each case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The L\/C ratio significantly decreased for 24\u2009months in patients with DME ( p\u2009=\u20090.01), whereas no significant differences were noted in other parameters including TCA, LA, SA, or CCT. Among patients treated with Laser\u2009\u00b1\u2009TA\u2009\u00b1\u2009IVA, a significant correlation was found between a high L\/C ratio at pretreatment and a lower cumulative number of injections (1\u20132 times\/24\u2009months) ( p\u2009=\u20090.04). The L\/C ratio in pretreatment showed a significantly inverse correlation with CMT (\u22120.60, p\u2009=\u20090.02) and subsequent BCVA (logMAR) (\u22120.59, p\u2009=\u20090.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study highlighted that the L\/C ratio in pretreatment might predict a change of the visual acuity in DME.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211027103","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T07:15:29Z","timestamp":1624432529000},"page":"450-459","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Involvements of choroidal vascular structures with local treatments in patients with diabetic macular edema"],"prefix":"10.1177","volume":"32","author":[{"given":"Satoru","family":"Kase","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuo","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Teine Yokoi Eye Clinic, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Katsuta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shozo","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kagoshima University, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiji","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kagoshima University, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, 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