{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:12:02Z","timestamp":1787019122053,"version":"build-2736575974"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T00:00:00Z","timestamp":1624752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To assess the impact of one intravitreal injection (IVT) of Triamcinolone Acetonide (TA) on intraocular pressure (IOP) and optic nerve structural parameters in patients treated for Diabetic Macular Edema (DME).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study included patients with DME that were na\u00efve to intraocular steroids and underwent one IVT of TA of 4 mg\/0.1 mL and age-matched controls with DME without criteria for IVT. Patients records were reviewed for IOP (at baseline and a month after IVT) and optic nerve parameters measured by optical coherence tomography (up to 6 months before and 6 months after IVT). Exclusion criteria included glaucoma and treatment with hypotensive agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-six eyes were included in the Control Group and 29 in the IVT Group, with a mean age of 65.10 \u00b1 10.08 and 67.30 \u00b1 4.71 years, respectively ( p = 0.06). At baseline, IOP and optic nerve measurements were equivalent between groups ( p &gt; 0.05). One month after IVT, mean IOP measurements in IVT Group were higher than those of controls (17.84 \u00b1 4.50 vs 11.59 \u00b1 3.09 mmHg, p &lt; 0.001). Ocular hypertension (OHT) developed in 17.24% of cases and reversed with topical medication. After one IVT, vertical cup\/disc ratio was higher (0.57 \u00b1 0.25 vs 0.60 \u00b1 0.14, p = 0.04) and retinal nerve fiber layer thickness was globally lower (mean: 91.03 \u00b1 4.25 vs 81.33 \u00b1 19.10 \u00b5m, p = 0.001) in the IVT Group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our results confirmed that intravitreal TA results in IOP increase. This seems to negatively affect optic nerve morphology, even in patients without OHT or adequately treated with hypotensive agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211028744","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T03:02:30Z","timestamp":1624762950000},"page":"1596-1601","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety of intravitreal triamcinolone and its impact on optic nerve morphology in patients treated for diabetic macular edema"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6130-2756","authenticated-orcid":false,"given":"Ana Rita","family":"Carreira","sequence":"first","affiliation":[{"name":"Hospital Garcia de Orta, E.P.E, Almada, 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