{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:34:43Z","timestamp":1777581283979,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study aimed to evaluate choroidal thickness (CT) and choroidal vascularity index (CVI) in patients with Graves\u2019 disease (GD) without ocular involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Fifty patients diagnosed with GD and 50 age and gender matched healthy control subjects were retrospectively evaluated. Measurements were taken from five different points on CT images. Choroid images were classified as lumen regions (LA) and stromal regions (SA) using the image binarization method. CVI was calculated by dividing LA by the total choroidal area (TCA). The effects of Thyrotropin Receptor Antibody (TRAb), age, GD duration, blood pressure, axial length measurements, and intraocular pressure were analyzed on CT and CVI measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean age was 40.1\u2009\u00b1\u200913.5\u2009years in the patient group and 39.3\u2009\u00b1\u200913.6\u2009years in the control group ( p\u2009=\u20090.89). There was no significant difference between the GD group and control group in terms of CT measurements. There was a significant difference between the mean CVI measurements of the GD group and control group (68.03\u2009\u00b1\u20093.41 and 66.62\u2009\u00b1\u20093.11, respectively) ( p\u2009&lt;\u20090.001). Univariate linear regression analysis revealed a positive correlation between TRAb and CVI ( p\u2009=\u20090.013).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>While there was no significant difference between the CT measurements of the GD group and the control group, the GD group had significantly higher CVI measurements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211031406","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T08:06:14Z","timestamp":1626077174000},"page":"1680-1686","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of choroidal circulation and stromal features in Graves\u2019 disease"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1513-7686","authenticated-orcid":false,"given":"Mustafa","family":"Aksoy","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Yuksek Ihtisas University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-5354","authenticated-orcid":false,"given":"Mert","family":"Simsek","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmut","family":"Apayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Afyonkarahisar University of Health Sciences, Afyonkarahisar, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"bibr1-11206721211031406","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200010263431707"},{"key":"bibr2-11206721211031406","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1306-5"},{"key":"bibr3-11206721211031406","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0239"},{"key":"bibr4-11206721211031406","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.03.012"},{"key":"bibr5-11206721211031406","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2007.03.015"},{"key":"bibr6-11206721211031406","first-page":"1025","volume":"53","author":"Farghaly H","year":"2012","journal-title":"J Nucl 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