{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:35:00Z","timestamp":1777581300067,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T00:00:00Z","timestamp":1627084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Von Hippel-Lindau syndrome is a rare autosomal dominantly inherited multisystemic oncologic syndrome, presenting predominantly with angiomatosis in embryologically similar neurologic tissue such as retina, cerebellum and adrenals. Retinal hemangioblastomas are the hallmark ophthalmic finding. In this case report, we describe the importance of timely diagnosis, thorough systemic examination and treatment of bilaterally asymmetrical retinal hemangioblastomas in a young adult male.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation:<\/jats:title>\n                    <jats:p>A 31-year-old male presented with painless diminution of vision in both eyes, associated with eyestrain and headache. Multiple asymmetric retinal lesions and dilated feeder vessels were noted on ophthalmoscopic examination and confirmed by fluorescein angiography to be retinal hemangioblastomas. Comprehensive systemic examination revealed cerebellar hemangioblastomas and multiple pancreatic and renal cysts. Treatment of retinal lesions was done by combination therapy of argon laser photocoagulation and cryopexy, which lead to a good visual outcome. Subsequently, neurosurgical resection of cerebellar hemangioblastoma proved to be lifesaving for the patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>RHBs are the earliest, easiest and the most frequently detected manifestation of VHL. Identification of ocular manifestations play a pivotal role in early diagnosis and timely intervention in VHL syndrome, thereby significantly reducing associated morbidity and mortality. Therefore, an ophthalmologist\u2019s role is crucial in the management of these potentially deadly tumours.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211035632","type":"journal-article","created":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T05:51:20Z","timestamp":1627105880000},"page":"NP5-NP9","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["How \u2018eye\u2019 helped in von Hippel-Lindau syndrome"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7601-9769","authenticated-orcid":false,"given":"Swati","family":"Tyagi","sequence":"first","affiliation":[{"name":"Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kritika Chopra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Komal","family":"Saluja","sequence":"additional","affiliation":[{"name":"Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,24]]},"reference":[{"issue":"9","key":"bibr1-11206721211035632","first-page":"3067","volume":"43","author":"Dollfus H","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr2-11206721211035632","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.175"},{"key":"bibr3-11206721211035632","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.181.4.1811049"},{"key":"bibr4-11206721211035632","doi-asserted-by":"publisher","DOI":"10.1007\/s003300050717"},{"key":"bibr5-11206721211035632","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.5.639"},{"key":"bibr6-11206721211035632","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021466"},{"key":"bibr7-11206721211035632","first-page":"119","volume":"19","author":"Molino D","year":"2006","journal-title":"J Nephrol"},{"key":"bibr8-11206721211035632","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-014-2660-0"},{"key":"bibr9-11206721211035632","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.154387"},{"key":"bibr10-11206721211035632","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.251"},{"key":"bibr11-11206721211035632","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-310047"},{"key":"bibr12-11206721211035632","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000254"},{"key":"bibr13-11206721211035632","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2014.07.007"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721211035632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721211035632","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721211035632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:44:49Z","timestamp":1777405489000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721211035632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,24]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1177\/11206721211035632"],"URL":"https:\/\/doi.org\/10.1177\/11206721211035632","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,24]]}}}