{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:37:28Z","timestamp":1784169448368,"version":"3.55.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the performance of serum cytokine IL-6 and IL-6\/IL-10 ratio as biomarkers for the diagnosis of primary open-angle glaucoma (POAG) and for determining its progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this study, 20 POAG patients and 21 healthy individuals from the Indonesian population were enrolled. The serum concentration of IL-6 and IL-10 were quantified. Comparative analysis was performed in addition to assessment of the diagnostic performance of cytokines using receiver-operating-curve (ROC) analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>POAG patients had a higher IL-6 ( p\u2009&lt;\u20090.0001) and IL-6\/IL-10 ratio ( p\u2009&lt;\u20090.0001) than controls. Among the POAG subjects, advanced-stage patients exhibited a higher IL-6\/IL-10 ratio than those in the early-moderate stage ( p\u2009=\u20090.001; p\u2009=\u20090.006). The ROC curve analysis showed that both IL-6 level and IL-6\/IL-10 ratio exhibited an excellent capability of diagnosing POAG (cut-off of 20.5\u2009pg\/mL (100% sensitivity and 94% specificity) and 4.4 (88% sensitivity and 94% specificity), respectively). Serum IL-6\/IL-10 ratio displayed a better performance than IL-6 in discriminating POAG severity with cut-off of at least 6.6 (sensitivity of 86% and specificity of 90%) and 9.1 (sensitivity of 89% and specificity of 78%) classified according to C\/D ratio and MD of VF, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The balance between IL-6 and IL-10 serum levels is potentially useful in discriminating POAG severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211037133","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T07:26:12Z","timestamp":1628839572000},"page":"2259-2264","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Serum IL-6\/IL-10 ratio as a biomarker for the diagnosis and severity assessment of primary-open 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Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad A\u2019raaf Sirojan","family":"Kusuma","sequence":"additional","affiliation":[{"name":"Undergraduate Medical Program, Faculty of Medicine and Health Sciences, Maulana Malik Ibrahim State Islamic University of Malang, Malang, Jawa Timur, 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