{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T21:25:20Z","timestamp":1787779520932,"version":"build-2784847793"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Myopia usually commences during primary school and progresses until the mean age of 16\u2009years. Topical low-dose (0.01%) atropine eye-drop appears to be safe and efficacious for myopia control in children. However, in some cases, a higher concentration of atropine is required in some cases because low-dose atropine treatment is not effective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a retrospective study among young myopic children between 5 and 15\u2009years with myopia progression\u2009&gt;\u20090.50\u2009D\/year. We selected patients treated with low-dose atropine (0.01%) eye-drops for 12\u2009months and conducted a comparative analysis of the group with good responder and poor responder. Patients were classified as good responders if spherical equivalent refractive error (SE) progression was\u2009\u2a7d\u20090.50\u2009D after 12\u2009months of treatment and poor responders if SE progression\u2009&gt;\u20090.50\u2009D. The prognostic factors before and after treatment were analyzed in two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 68 eyes were included. Low-dose (0.01%) atropine eye-drops have a good treatment response in 54% of patients. In the good responder group ( n\u2009=\u200937), the mean rate of myopia progression after 12\u2009months of treatment (0.36\u2009\u00b1\u20090.17\u2009D) was significantly slower compared with the baseline progression ( p\u2009&lt;\u20090.001). Good responders have smaller changes in axial length (AL) elongation and SE than poor responders ( p\u2009&lt;\u20090.001). The only adverse event was temporary near vision difficulty (10%), photophobia (10%), and mild pupil dilation (30%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The AL elongation is an important indicator for monitoring the treatment response. Children with a family history of myopia at a young age may not respond well to low-dose (0.01%) atropine eye-drops. In these cases, increasing the concentration of atropine eye-drops should be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211038817","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T02:07:00Z","timestamp":1629166020000},"page":"2011-2017","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of treatment response about low-dose (0.01%) atropine eye-drops in myopic children"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4792-5372","authenticated-orcid":false,"given":"Gang Seok","family":"Jeon","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Dasan Samsung Bright Eye Clinic, Gyeonggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Hwan","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dongtan Sacred Heart Hospital, College of Medicine, Hallym University, Hwaseong, Gyeonggi, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dasan Samsung Bright Eye Clinic, Gyeonggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Geun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dasan Samsung Bright Eye Clinic, Gyeonggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Yeem","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Galmae Samsung Bright Clinic, Gyeonggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Ryong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dongtan Sacred Heart Hospital, College of Medicine, Hallym University, Hwaseong, Gyeonggi, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"bibr1-11206721211038817","doi-asserted-by":"publisher","DOI":"10.1038\/519276a"},{"key":"bibr2-11206721211038817","doi-asserted-by":"publisher","DOI":"10.3390\/diseases6040092"},{"key":"bibr3-11206721211038817","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12403"},{"key":"bibr4-11206721211038817","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.2011.00884.x"},{"key":"bibr5-11206721211038817","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.11.010"},{"key":"bibr6-11206721211038817","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.07.004"},{"key":"bibr7-11206721211038817","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.1091"},{"key":"bibr8-11206721211038817","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14166"},{"key":"bibr9-11206721211038817","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.07.031"},{"key":"bibr10-11206721211038817","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2015.0043"},{"key":"bibr11-11206721211038817","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.03.018"},{"key":"bibr12-11206721211038817","volume":"10","author":"Huang 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