{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:22:33Z","timestamp":1784949753319,"version":"3.55.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Eye Cancer Foundation","award":["Fellowship Grant to Dr. Ankit Tomar"],"award-info":[{"award-number":["Fellowship Grant to Dr. Ankit Tomar"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To determine a reliable diagnostic method to reveal and monitor subclinical progression of neural and perineural radiation vasculopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective cross-sectional study, where optical coherence tomography angiography (OCT-A) imaging data was collected and analyzed from 22 consecutive patients that had been treated with circumneural slotted plaque brachytherapy for peripapillary, juxtapapillary, or circumpapillary choroidal melanomas. Pre-operative dosimetry of palladium-103 radiation dose to the optic nerve and fovea were collected. Quantified differences in OCT-A-measured vessel density and length in treated verses untreated contralateral control eyes were collected. Vessel density and length were correlated to radiation dose, plaque slot depth, visual acuity outcomes, and circumpapillary retinal nerve fiber layer thickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Patients had post-irradiation follow-up of median 39 months, interquartile range 62 months). The mean optic disc radiation dose was 89.9 Gy \u00b1 39.2 (86.5, 30.8\u2013189.0). In comparison to controls, OCT-A imaging revealed significant differences in radial peripapillary capillary vessel density (18 \u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      in case eyes, 34 \u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      in control eyes; p &lt; 0.001) and length (10 \u03bcm in case eyes, 14 \u03bcm in control eyes; p &lt; 0.001). Change in vessel density did not show a significant correlation to radiation dose, slot depth, or visual acuity. However, change in vessel length was significantly correlated to radiation dose ( p = 0.049) and change in visual acuity ( p &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>OCT-A imaging revealed that radial peripapillary capillary vessel density and length were significantly reduced after circumneural irradiation for choroidal melanoma. Therefore, OCT-A imaging can be used to monitor progression of papillary vasculopathy associated with radiation optic neuropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211044339","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T06:53:38Z","timestamp":1631775218000},"page":"2459-2568","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["OCT-A evaluation of radiation vasculopathy following slotted plaque brachytherapy"],"prefix":"10.1177","volume":"32","author":[{"given":"Anthony","family":"Fam","sequence":"first","affiliation":[{"name":"The New York Eye Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit S","family":"Tomar","sequence":"additional","affiliation":[{"name":"The New York Eye Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8111-3896","authenticated-orcid":false,"given":"Paul T","family":"Finger","sequence":"additional","affiliation":[{"name":"The New York Eye Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"bibr1-11206721211044339","doi-asserted-by":"publisher","DOI":"10.4103\/2008-322X.200162"},{"key":"bibr2-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-015-0005-8"},{"key":"bibr3-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.21.6.065002"},{"key":"bibr4-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.07.054"},{"key":"bibr5-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2009.06.004"},{"key":"bibr6-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1991.39"},{"key":"bibr7-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.114082"},{"key":"bibr8-11206721211044339","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20111129-09"},{"issue":"3","key":"bibr9-11206721211044339","first-page":"233","volume":"1","author":"Behbehani R","year":"2007","journal-title":"Clin Ophthalmol"},{"issue":"12","key":"bibr10-11206721211044339","first-page":"1071","volume":"47","author":"Yang H","year":"2011","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"bibr11-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2013.11.008"},{"key":"bibr12-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2007.09.004"},{"key":"bibr13-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.09.014"},{"key":"bibr14-11206721211044339","doi-asserted-by":"publisher","DOI":"10.5301\/EJO.2011.6213"},{"key":"bibr15-11206721211044339","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000670"},{"key":"bibr16-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.10.026"},{"key":"bibr17-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2007.9"},{"key":"bibr18-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.01.025"},{"key":"bibr19-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.7.969"},{"key":"bibr20-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.037"},{"key":"bibr21-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.3.305"},{"key":"bibr22-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199616020-00008"},{"key":"bibr23-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2017.06.005"},{"key":"bibr24-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002680"},{"key":"bibr25-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000655"},{"key":"bibr26-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205773"},{"issue":"9","key":"bibr27-11206721211044339","volume":"57","author":"Kim AY","year":"2016","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bibr28-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-311389"},{"key":"bibr29-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18877"},{"key":"bibr30-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.01.032"},{"key":"bibr31-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.9.1202"},{"key":"bibr32-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135151"},{"key":"bibr33-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1118\/1.4749933"},{"key":"bibr34-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)00088-X"},{"key":"bibr35-11206721211044339","doi-asserted-by":"publisher","DOI":"10.1080\/17469899.2020.1781618"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721211044339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721211044339","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721211044339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:44:57Z","timestamp":1777405497000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721211044339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,16]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1177\/11206721211044339"],"URL":"https:\/\/doi.org\/10.1177\/11206721211044339","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,16]]}}}