{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:35:43Z","timestamp":1777581343756,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:00:00Z","timestamp":1634342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To describe an atypical nodular episcleritis mimicking a solitary giant episcleral mass, which is not attributed to any systemic diseases and identified only after immunohistochemical examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A sixty-year-old Chinese woman with systemic hypertension presented with 6-month history of giant, solitary and redness epibulbar mass arising from the superior aspect of her left eye. The lesion gradually enlarged, even with 6-month history of irregular topical steroid eye drops treatment. Imaging studies and laboratory test revealed a 10\u2005mm\u2009\u00d7\u20098\u2005mm episcleral mass absence of any infection indicator and autoimmune antibody changes. The mass was completely removed before its extension through the deep scleral, histopathologic examination revealed a nodular episcleritis composed of various chronic inflammatory cells infiltration. Topical steroid eye drops treatment combined with oral steroidal anti-inflammatory drugs was then administrated regularly for 1 month, and no recurrence occurred after 1-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nodular anterior episcleritis is characterized by underlying chronic inflammation of the anterior episclera and can be presented as asymptomatic episcleral mass. Besides a thorough investigation systemically, tissue biopsy is required for definite diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211052879","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T05:10:31Z","timestamp":1634361031000},"page":"NP31-NP34","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A case of nodular episcleritis mimicking a solitary giant episcleral mass"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7785-5598","authenticated-orcid":false,"given":"Lan","family":"Zhou","sequence":"first","affiliation":[{"name":"Ophthalmological Center of Huizhou Municipal Central Hospital, Huizhou, Guangdong 516000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanjuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Ophthalmological Center of Huizhou Municipal Central Hospital, Huizhou, Guangdong 516000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guihua","family":"Xu","sequence":"additional","affiliation":[{"name":"Ophthalmological Center of Huizhou Municipal Central Hospital, Huizhou, Guangdong 516000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingding","family":"Wang","sequence":"additional","affiliation":[{"name":"Ophthalmological Center of Huizhou Municipal Central Hospital, Huizhou, Guangdong 516000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Ophthalmological Center of Huizhou Municipal Central Hospital, Huizhou, Guangdong 516000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilin","family":"Chen","sequence":"additional","affiliation":[{"name":"Ophthalmological Center of Huizhou Municipal Central Hospital, Huizhou, Guangdong 516000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,10,16]]},"reference":[{"key":"bibr1-11206721211052879","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.60.3.163"},{"key":"bibr2-11206721211052879","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.07.013"},{"key":"bibr3-11206721211052879","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31325-X"},{"key":"bibr4-11206721211052879","doi-asserted-by":"publisher","DOI":"10.1159\/000486421"},{"key":"bibr5-11206721211052879","doi-asserted-by":"publisher","DOI":"10.3109\/01676830.2013.764447"},{"key":"bibr6-11206721211052879","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-017-1416-y"},{"key":"bibr7-11206721211052879","first-page":"8689463","volume":"2020","author":"Sarah B","year":"2020","journal-title":"Case Rep Ophthalmol Med"},{"key":"bibr8-11206721211052879","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.01.033"},{"key":"bibr9-11206721211052879","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.04.018"},{"key":"bibr10-11206721211052879","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.07.043"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721211052879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721211052879","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721211052879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:45:13Z","timestamp":1777405513000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721211052879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,16]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1177\/11206721211052879"],"URL":"https:\/\/doi.org\/10.1177\/11206721211052879","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,16]]}}}