{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:35:34Z","timestamp":1777581334475,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Anti-TNF-\u03b1-induced lupus (ATIL) is a rare condition considered as a drug-induced lupus (DIL) in patients under anti-TNF-\u03b1 therapies. Nowadays it is still unclear if ATIL is a classical DIL or represent a distinct syndrome. Some characteristics of DIL have been described specifically associated with patients with lupus-like syndrome receiving anti-TNF-\u03b1 therapy: the severity of the disease, incidence\/prevalence of dsDNA antibodies (anti-dsDNA) and hypocomplementaemia. The objective of this study is to describe the development of ATIL in patients with non-infectious uveitis in a single tertiary center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective description of a case series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We describe three patients with noninfectious uveitis (NIU) of different etiologies who developed antinuclear antibody (ANA) and anti-dsDNA antibody positivity, arthritis and, in one case, skin lesions under adalimumab treatment. The condition resolved in all of them after adalimumab withdrawal. Corticosteroids were required in one patient, non-steroidal anti-inflammatory drugs in two patients, and hydroxychloroquine in one of them. None required another immunosuppressive drug. A subsequent control of the NIU could continue to be carried out without anti-TNF-\u03b1 therapy in two patients and in the remaining a switch was made to another anti-TNF-\u03b1 (golimumab).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current report describes three cases of ATIL in patients with different types of NIU which share some common features: ANA positivity, articular symptoms, and a temporal relationship between symptoms onset and anti-TNF-\u03b1 treatment. A review of the literature and comparison with the few previous reported ATIL cases was conducted as well.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211054705","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T07:24:05Z","timestamp":1636529045000},"page":"NP39-NP43","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti-TNF-alpha-induced lupus in patients with non-infectious uveitis"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2230-5898","authenticated-orcid":false,"given":"Lucia","family":"Miguel-Escuder","sequence":"first","affiliation":[{"name":"Cl\u00ednic Institute of Ophthalmology, Hospital Clinic, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Garcia Tirado","sequence":"additional","affiliation":[{"name":"Cl\u00ednic Institute of Ophthalmology, Hospital Clinic, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Sainz-de-la-Maza","sequence":"additional","affiliation":[{"name":"Cl\u00ednic Institute of Ophthalmology, Hospital Clinic, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4753-2111","authenticated-orcid":false,"given":"Aina","family":"Moll-Udina","sequence":"additional","affiliation":[{"name":"Cl\u00ednic Institute of Ophthalmology, Hospital Clinic, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"Lloren\u00e7","sequence":"additional","affiliation":[{"name":"Cl\u00ednic Institute of Ophthalmology, Hospital Clinic, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0182-7950","authenticated-orcid":false,"given":"Alba","family":"Parrado-Carrillo","sequence":"additional","affiliation":[{"name":"Cl\u00ednic Institute of Ophthalmology, Hospital Clinic, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Ad\u00e1n","sequence":"additional","affiliation":[{"name":"Cl\u00ednic Institute of Ophthalmology, Hospital Clinic, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"bibr1-11206721211054705","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2005.12.012 2"},{"key":"bibr2-11206721211054705","unstructured":"https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/humira (accessed 9 December 2020)."},{"key":"bibr3-11206721211054705","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1361.100"},{"key":"bibr4-11206721211054705","doi-asserted-by":"publisher","DOI":"10.4065\/84.11.979"},{"key":"bibr5-11206721211054705","doi-asserted-by":"publisher","DOI":"10.1186\/ar1715"},{"key":"bibr6-11206721211054705","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181441a68"},{"key":"bibr7-11206721211054705","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509852"},{"key":"bibr8-11206721211054705","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.08.003"},{"key":"bibr9-11206721211054705","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2361-9"},{"key":"bibr10-11206721211054705","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep080"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721211054705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721211054705","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721211054705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:45:14Z","timestamp":1777405514000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721211054705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,10]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1177\/11206721211054705"],"URL":"https:\/\/doi.org\/10.1177\/11206721211054705","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,10]]}}}