{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:35:50Z","timestamp":1777581350476,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate if symptomatic conjunctivitis during the recovery phase of the disease could be associated to a persistent presence of SARS-CoV-2 in the upper respiratory tract. Secondary end points were to analyze the presence of SARS-CoV-2 in the conjunctiva of ocular symptomatic patients and to record the presence of ocular disturbances at this point of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An observational study including consecutive COVID19 patients treated at Humanitas Clinical and Research Hospital who were attending for nasopharyngeal swab to confirm the resolution of SARS-CoV-2 infection and end of isolation. We examined 129 consecutive patients from May to June 2020. The primary end point was to determine if symptomatic conjunctivitis at this point of the disease could be associated to a persistent presence of SARS-CoV-2 in the upper respiratory tract. Secondary end points were to analyze the presence of SARS-CoV-2 in the conjunctiva of ocular symptomatic patients and to record the presence of ocular disturbances at this point of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred twenty eight patients were included, 9.38% had conjunctivitis, none resulted positive to conjunctival PCR swab test, while two of them had positive nasopharyngeal result. Mean time elapsed since the first COVID-19 positive swab to the time of examination was 6 weeks (\u2009\u2009\u00b1\u20093). The only significant association was the presence of conjunctivitis with older age (65.3\u2009\u2009\u00b1\u2009\u200912.7 vs 56.7\u2009\u2009+\u2009\u200913.5. p\u2009\u2009=\u2009\u20090.046). Nasopharyngeal swab resulted positive in 22 patients (17.19%). While 88 patients (68.2%) did not have any ocular complain during their COVID19 disease. The 40 patients (31.8%) reporting ocular disturbances complained about: redness (25.43%), tearing (19.53%), burning (18.35%), foreign body sensation (17.18%), itching (15.62%), and discharge (12.5%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study showed that late conjunctivitis cannot be considered as a marker of persistent infection when patients are sent to confirm the resolution of SARS-CoV-2 infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211056594","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T07:43:02Z","timestamp":1636616582000},"page":"830-835","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Conjunctivitis as a sign of persistent SARS-COV-2 infection? An observational study and report of late symptoms"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9710-8875","authenticated-orcid":false,"given":"Jose Luis","family":"Vallejo-Garcia","sequence":"first","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Balia","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8472-7984","authenticated-orcid":false,"given":"R","family":"Raimondi","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Rustioni","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FI","family":"Camesasca","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Borgia","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Fossati","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Confalonieri","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2694-2816","authenticated-orcid":false,"given":"EF","family":"Legrottaglie","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Casari","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MT","family":"Sandri","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3864-8246","authenticated-orcid":false,"given":"P","family":"Vinciguerra","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"bibr1-11206721211056594","doi-asserted-by":"crossref","unstructured":"Cable J, Heymann DL, Uzicanin A, et al. Concise original report pandemic diseases preparedness and response in the age of COVID-19\u2014a symposium report. 2020; 1\u201313.","DOI":"10.1111\/nyas.14534"},{"key":"bibr2-11206721211056594","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13089"},{"key":"bibr3-11206721211056594","unstructured":"ISARIC; 2020. International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC). COVID-19 Report: 19 May 2020 [Internet]. [cited 2020 Nov 8]. Available from: https:\/\/media.tghn.org\/medialibrary\/2020\/05\/ISARIC_Data_Platform_COVID-19_Report_19MAY20.pdf. Accessed 20 November 2020."},{"key":"bibr4-11206721211056594","author":"Zhang JJY","journal-title":"Clin Infect Dis, Off Publ Infect Dis Soc Am"},{"key":"bibr5-11206721211056594","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202003-0736LE"},{"key":"bibr6-11206721211056594","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2020.35.e142"},{"key":"bibr7-11206721211056594","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-020-01442-7"},{"key":"bibr8-11206721211056594","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2020.1291"},{"key":"bibr9-11206721211056594","doi-asserted-by":"publisher","DOI":"10.7326\/M20-0504"},{"key":"bibr10-11206721211056594","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30243-7"},{"key":"bibr11-11206721211056594","author":"Li N","year":"2020","journal-title":"J Med Virol [Internet]"},{"key":"bibr12-11206721211056594","unstructured":"Centers for Disease Control and Prevention (CDC). Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Disease (COVID-19) [Internet]. [cited 2020 Nov 13]. 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