{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:35:51Z","timestamp":1777581351183,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To describe a case of macular intraretinal microvascular abnormality (IRMA) detected with Optical Coherence Tomography Angiography (OCTA) and to show its remodeling and vascular density changes after panretinal photocoagulation (PRP) during an 18-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Case report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A 22-year-old female patient with proliferative diabetic retinopathy was found to have a small hyperreflective formation with posterior shadow cone and signal flow, located at the temporal margin of the fovea avascular zone (FAZ), identified as macular IRMA with OCTA. Her best-corrected-visual acuity was 20\/20. Four months later the macular IRMA was larger and, in its context, there was also an increase in the flow area in B-scan. The patient underwent PRP and after 18 months we observed a regression of macular IRMA and an increase in the superficial capillary plexus vessel density in all sectors in comparison to baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OCTA is a non-invasive tool that recognize macular IRMA in diabetic retinopathy patient and it could be helpful to follow their qualitative and quantitative vascular evolution over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211059014","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T06:11:01Z","timestamp":1636438261000},"page":"NP123-NP126","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["OCTA in macular intraretinal microvascular abnormalities: Retinal vascular density remodeling after panretinal photocoagulation"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5798-1899","authenticated-orcid":false,"given":"Federica","family":"Fossataro","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples \u201cFederico II\u201d, Naples, Italy"},{"name":"Eye Clinic, Melegnano Hospital, Vizzolo Predabissi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Rispoli","sequence":"additional","affiliation":[{"name":"Eye Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Pece","sequence":"additional","affiliation":[{"name":"Eye Clinic, Melegnano Hospital, Vizzolo Predabissi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"bibr1-11206721211059014","doi-asserted-by":"publisher","DOI":"10.1089\/pop.2015.0181"},{"key":"bibr2-11206721211059014","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1005073"},{"issue":"5","key":"bibr3-11206721211059014","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0161-6420(13)38012-9","volume":"98","author":"Early Treatment Diabetic Retinopathy Study Research Group","year":"1991","journal-title":"Ophthalmology"},{"key":"bibr4-11206721211059014","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.09.041"},{"key":"bibr5-11206721211059014","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20210"},{"key":"bibr6-11206721211059014","doi-asserted-by":"publisher","DOI":"10.1159\/000492897"},{"key":"bibr7-11206721211059014","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(87)33524-9"},{"key":"bibr8-11206721211059014","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.37.5.282"},{"key":"bibr9-11206721211059014","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002671"},{"key":"bibr10-11206721211059014","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.3.34"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721211059014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721211059014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721211059014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:45:20Z","timestamp":1777405520000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721211059014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,9]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1177\/11206721211059014"],"URL":"https:\/\/doi.org\/10.1177\/11206721211059014","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,9]]}}}