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Demographics, clinical features, diagnostic work-up, treatment and prognostic data from the published literature are discussed. Ninety-five patients with orbital metastases from neuroendocrine tumours have been reported so far. Average age at presentation is 63.8 years (range 25\u201386), with no significant gender predominance. Gastrointestinal tract is the most common site of primary neuroendocrine tumours (62\u201385%). Typical presentation includes proptosis (80\u201385%) and diplopia (27\u201362%) in patients with known primary neuroendocrine tumour elsewhere. Histological subtype and presence of metastases seem to be important prognostic factors. Incidental finding of neuroendocrine tumour mestastases in asymptomatic patients with unknown primary disease is uncommon. In such cases, orbital biopsy and structural and functional imaging are essential to establish a diagnosis and stage the disease.<\/jats:p>","DOI":"10.1177\/11206721211060633","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T06:57:29Z","timestamp":1637132249000},"page":"2498-2504","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Orbital metastasis from neuroendocrine tumour: Case report and literature review"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-2654","authenticated-orcid":false,"given":"Giorgio","family":"Albanese","sequence":"first","affiliation":[{"name":"Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreemathi","family":"Harieaswar","sequence":"additional","affiliation":[{"name":"Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghavan","family":"Sampath","sequence":"additional","affiliation":[{"name":"Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11105"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/01676830902897470"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1983.01040020397012"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2470"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-620X.91268"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e3282c5077c"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e31818b6d02"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01470.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/01676830.2019.1576739"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-234629"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjopt.2018.07.003"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/01676830903403166"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-02130-5"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.10.051"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(71)91218-9"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197609)38:3<1326::AID-CNCR2820380336>3.0.CO;2-#"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.60.8.583"},{"key":"e_1_3_3_19_2","first-page":"919","article-title":"Ileo-cecal malignant carcinoid tumor with orbital metastases as initial symptoms. 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