{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:36:10Z","timestamp":1777581370784,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Early diagnosis and initiation of immunosuppression can prevent the necessity of surgical intervention in necrotizing scleritis with inflammation and lowers the risk of perforation and loss of vision. However, clinical signs for early diagnosis and methods for monitoring response to immunosuppressive therapy are missing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we present a case of necrotizing scleritis with inflammation where avascular plaques precede scleral defects. We use slit lamp imaging and anterior segment optical coherence tomography to evaluate evolution lesions depth and impact on scleral structure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patient presented 5 months after detection of avascular plaques with a new scleral ulcer of the left eye. After 3-day-administration of i.v. corticosteroids anterior segment optical coherence tomography showed progressive scleral thickening. The patient was therefore spared surgical intervention and discharged resulting in complete remission under decreasing doses of oral corticosteroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Avascular plaques can precede necrotizing scleritis with inflammation by several months and may therefore qualify as early clinical signs. Anterior segment optical coherence tomography enables objective evaluation of scleral structure for making rational decisions about surgical intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721211065564","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T05:58:34Z","timestamp":1638770314000},"page":"NP35-NP38","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Monitoring therapy in anterior necrotizing scleritis with inflammation with anterior segment optical coherence tomography"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6225-1521","authenticated-orcid":false,"given":"Lourdes","family":"Vidal Oliver","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8793-2107","authenticated-orcid":false,"given":"Ana","family":"L\u00f3pez Montero","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3884-7226","authenticated-orcid":false,"given":"Irene","family":"Gil Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca","family":"Garc\u00eda Ibor","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Vela Bernal","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Miguel","family":"Duch Samper","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"bibr1-11206721211065564","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.07.013"},{"key":"bibr2-11206721211065564","volume-title":"Uve\u00edtis y escleritis. Diagn\u00f3stico y tratamiento","author":"D\u00edaz M","year":"2014"},{"key":"bibr3-11206721211065564","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00710-8"},{"key":"bibr4-11206721211065564","volume":"00","author":"Hau SC","year":"2019","journal-title":"Ocul Immunol Inflamm"},{"key":"bibr5-11206721211065564","volume":"196","author":"Miyata M","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"bibr6-11206721211065564","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-015-0153-8"},{"key":"bibr7-11206721211065564","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-308561"},{"key":"bibr8-11206721211065564","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.08.027"},{"key":"bibr9-11206721211065564","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.11.003"},{"key":"bibr10-11206721211065564","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2127"},{"key":"bibr11-11206721211065564","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.03.004"},{"key":"bibr12-11206721211065564","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2015.1025983"},{"key":"bibr13-11206721211065564","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2019.1620805"},{"key":"bibr14-11206721211065564","volume-title":"Uveitis fundamentals and clinical practice","author":"Nussenblatt RB","year":"2010","edition":"4"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721211065564","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721211065564","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721211065564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:45:28Z","timestamp":1777405528000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721211065564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,6]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1177\/11206721211065564"],"URL":"https:\/\/doi.org\/10.1177\/11206721211065564","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,6]]}}}