{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:36:16Z","timestamp":1777581376863,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"\n Purpose<\/jats:title>\n To evaluate the occurrence of transient central retinal artery occlusion following intravitreal anti-vascular endothelial growth factor injection.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Prospective, observational study of 807 patients (807 eyes) who were given intravitreal injections of ranibizumab or aflibercept to treat any cause of retinal vascular diseases between 1 January 2017 and 30 November 2018 at the Federal Fluminense University Hospital in Niteroi, and a private facility in Rio de Janeiro, Brazil. Patients who did not present transient central retinal artery occlusion were excluded.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 4069 injections, only 18 patients (0.44%) presented transient central retinal artery occlusion, 14 mild cases (77.7%), and 4 severe cases (22.3%). The clinical factors associated with more severe cases of transient central retinal artery occlusion were the duration of the transient central retinal artery occlusion (\n p<\/jats:italic>\n \u2009=\u20090.001), number of prior injections (\n p<\/jats:italic>\n \u2009=\u20090.01), and a positive carotid Doppler test (\n p<\/jats:italic>\n \u2009=\u20090.01). Twelve cases (66.6%) had positive carotid artery obstruction (atheroma plaque size \u226570%) while 6 cases (33.3%) had negative carotid artery obstruction (atheroma plaque size <70%). The age group >60 years old (\n p<\/jats:italic>\n \u2009=\u20090.06), cup\/disc ratio >0.6 (\n p<\/jats:italic>\n \u2009=\u20090.06), and pseudophakic lens status were also factors with association with transient central retinal artery occlusion, although did not meet criteria for statistical significance. The only patient who experienced a recurrent episode of transient central retinal artery occlusion had diabetic macular edema, positive carotid Doppler test, and cup\/optic disc ratio >0.6.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Transient central retinal artery occlusion is a rare adverse event that can appear in patients with retinal vascular disease receiving anti-vascular endothelial growth factor therapy. The atheroma plaque size and the number of prior injections can be associated with the severity of the event.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/11206721211066196","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T06:06:14Z","timestamp":1640671574000},"page":"2819-2823","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Transient central retina artery occlusion in patients undergoing intravitreal anti vegf injections"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7881-3584","authenticated-orcid":false,"given":"Nadyr A","family":"Damasceno","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Marcilio Dias Navy Hospital, Rio de Janeiro, RJ, Brazil"},{"name":"Department of Ophthalmology, Federal University of S\u00e3o Paulo, Paulista Medical School, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas A","family":"Yannuzzi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Maia","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Federal University of S\u00e3o Paulo, Paulista Medical School, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Eid Farah","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Federal University of S\u00e3o Paulo, Paulista Medical School, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Harry W","family":"Flynn","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo F","family":"Damasceno","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Federal Fluminense University, School of Medicine, Niteroi, RJ, 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