{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:37:49Z","timestamp":1777581469769,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To compare the long-term outcomes in chronic central serous chorioretinopathy (cCSC) following half-fluence photodynamic therapy (HF-PDT) and oral eplerenone treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective comparative study included consecutive patients of cCSC treated with either HF-PDT or eplerenone. The treatment outcomes of the two groups were analyzed at 3-month, 6-month, and 12-month post-treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>This study included 20 eyes (20 patients) in HF-PDT group, and 18 eyes (18 patients) in eplerenone group. All baseline parameters in HF-PDT and eplerenone groups were comparable including neurosensory detachment height (217.05\u2009\u00b1\u2009140.25\u2009\u00b5m vs 178.05\u2009\u00b1\u2009164.24\u2009\u00b5m respectively, p\u2009=\u20090.09), best-corrected visual acuity (BCVA) (logMAR 0.24\u2009\u00b1\u20090.13 vs logMAR 0.46\u2009\u00b1\u20090.37 respectively, p\u2009=\u20090.1), and subfoveal choroidal thickness (SFCT) [427.4\u2009\u00b1\u2009117.4\u2009\u00b5m vs 456.38\u2009\u00b1\u2009119.25\u2009\u00b5m respectively, p\u2009=\u20090.45]. HF-PDT resulted in complete resolution of neurosensory detachment in higher proportion of eyes compared to eplerenone at each follow-up visits (3\u2009months: 90% vs 27.7%, p\u2009=\u20090; 6\u2009months: 100% vs 61.1%, p\u2009=\u20090.003; and 12\u2009months: 100% vs 70%, p\u2009=\u20090.03) with a significantly shorter duration to resolution (3.3\u2009\u00b1\u20090.9\u2009months vs 5.8\u2009\u00b1\u20093.3\u2009months respectively, p\u2009=\u20090.02). Intergroup comparison showed no significant difference between mean BCVA ( p\u2009=\u20090.38 at 3\u2009months, p\u2009=\u20090.14 at 6\u2009months, and p\u2009=\u20090.19 at 12\u2009months). Mean SFCT at 12\u2009months of the two groups differed significantly ( p\u2009=\u20090.003) due to increased choroidal thickness of eplerenone group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>HF-PDT has a superior efficacy to achieve faster, greater and long-lasting resolution of subretinal fluid in cCSC compared to eplerenone therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672121991053","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T01:36:47Z","timestamp":1611884207000},"page":"3110-3116","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Long-term outcomes of half-fluence photodynamic therapy and eplerenone in chronic central serous chorioretinopathy: A comparative study"],"prefix":"10.1177","volume":"31","author":[{"given":"George","family":"Manayath","sequence":"first","affiliation":[{"name":"Department of Retina and Vitreous Services, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4295-8949","authenticated-orcid":false,"given":"Shishir","family":"Verghese","sequence":"additional","affiliation":[{"name":"Department of Retina and Vitreous Services, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9410-4649","authenticated-orcid":false,"given":"Ratnesh","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Department of Retina and Vitreous Services, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, 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