{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:56:51Z","timestamp":1782143811279,"version":"3.54.5"},"reference-count":12,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801381"],"award-info":[{"award-number":["81801381"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Importance:<\/jats:title>\n                    <jats:p>This is the first reported case of acute exudative paraneoplastic polymorphous vitelliform maculopathy (AEPPVM) in a patient with thymoma, accompanied by myasthenia gravis (MG) and polymyositis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To examine the pathogenesis of ocular disease in a patient with yolk-like fundus lesions and thymoma, MG, and polymyositis throughout the body based on clinical manifestations, diagnosis, differential diagnosis, and genetic testing to determine the appropriate treatment course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, and participants:<\/jats:title>\n                    <jats:p>We describe a 63-year-old woman who presented to our tertiary medical center with a 3-month history of reduced visual acuity in both eyes. Concurrent fundoscopy revealed a 2.0\u2009\u00d7\u20091.7-mm, unifocal, yellow, round vitelliform lesion in the macular region, surrounded by multifocal, shallow, yellow-white pockets of subretinal fluid. The patient\u2019s medical history included thymoma with thymectomy treatment, combined with pericardiectomy and postoperative radiotherapy (20\u2009years prior), followed by a diagnosis of MG with suspect thymic association (15\u2009years prior). Three years prior, the patient had been diagnosed with polymyositis related to paraneoplastic syndrome; 1\u2009year prior, she had been examined for pleural thickening due to suspected metastatic tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>On her most recent follow-up visit at 3\u2009months after initial diagnosis, the patient was stable with no clinically significant progression in ocular or systemic conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1120672121994042","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T05:54:31Z","timestamp":1614059671000},"page":"NP56-NP61","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute exudative paraneoplastic polymorphous vitelliform maculopathy in a patient with thymoma, myasthenia gravis, and polymyositis"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4101-8365","authenticated-orcid":false,"given":"He","family":"Yu","sequence":"first","affiliation":[{"name":"Ophthalmologic Center, Qingdao Municipal Hospital, Qingdao, Shandong, P.R. China"},{"name":"Graduate School, Dalian Medical University, Dalian, Liaoning, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Ma","sequence":"additional","affiliation":[{"name":"Ophthalmologic Center, Qingdao Municipal Hospital, Qingdao, Shandong, P.R. China"},{"name":"Graduate School, Dalian Medical University, Dalian, Liaoning, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianting","family":"Tong","sequence":"additional","affiliation":[{"name":"Ophthalmologic Center, Qingdao Municipal Hospital, Qingdao, Shandong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Ophthalmologic Center, Qingdao Municipal Hospital, Qingdao, Shandong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7286-8624","authenticated-orcid":false,"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ophthalmologic Center, Qingdao Municipal Hospital, Qingdao, Shandong, P.R. China"},{"name":"The Affiliated Municipal Hospital of Qingdao University, Qingdao, Shandong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"bibr1-1120672121994042","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20170928-11"},{"key":"bibr2-1120672121994042","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-858840"},{"key":"bibr3-1120672121994042","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.215"},{"key":"bibr4-1120672121994042","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20120712-01"},{"key":"bibr5-1120672121994042","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20161130-09"},{"key":"bibr6-1120672121994042","first-page":"354","volume":"86","author":"Gass JD","year":"1988","journal-title":"Trans Am Ophthalmol Soc"},{"key":"bibr7-1120672121994042","doi-asserted-by":"publisher","DOI":"10.1080\/09273940590928733"},{"key":"bibr8-1120672121994042","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(76)90125-2"},{"key":"bibr9-1120672121994042","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0002-9394(98)00212-8","volume":"126","author":"Keltner JL","year":"1998","journal-title":"Am J Ophthalmol"},{"key":"bibr10-1120672121994042","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76622-X"},{"key":"bibr11-1120672121994042","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2020.100870"},{"key":"bibr12-1120672121994042","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.07.020"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672121994042","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1120672121994042","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1120672121994042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:45:47Z","timestamp":1777405547000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1120672121994042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1177\/1120672121994042"],"URL":"https:\/\/doi.org\/10.1177\/1120672121994042","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,23]]}}}