{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:39:53Z","timestamp":1777581593540,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NO.81400375,81970772,81670817,81670816"],"award-info":[{"award-number":["NO.81400375,81970772,81670817,81670816"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to explore the pterygium formation and recurrence, by detecting the expression of Nod-like receptor pyrin domain 3 (NLRP3) and Nod-like receptor pyrin domain 6 (NLRP6) in pterygium and evaluate the correlation between NLRP3 and NLRP6 in pterygium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective study, the expression levels of NLRP3 and NLRP6, with their related effectors, were evaluated in primary pterygium (n\u2009=\u200940) and recurrent pterygium (n\u2009=\u200932) tissue samples and compared with normal conjunctiva (n\u2009=\u200911) tissue samples by immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to the normal conjunctiva group, the expression levels of NLRP3, caspase-1, IL-18, and IL-1\u03b2, were significantly higher, and NLRP6 showed an expression that was significantly lower in pterygium tissue samples (P &lt; 0.05, respectively). Compared to the primary pterygium group, the expression levels of NLRP3, caspase-1, IL-18 and IL-1\u03b2 were significantly higher, and NLRP6 showed an expression that was significantly lower in recurrent pterygium tissue samples (P &lt; 0.05, respectively).There was a negative correlation between NLRP3 expression and NLRP6 expression in normal conjunctival (r\u2009=\u2009\u22120.739, P\u2009=\u20090.009) and pterygium (r\u2009=\u2009\u22120.533, P\u2009=\u20090.000).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NLRP3 and NLRP6 may be involved in the formation and recurrence of pterygium. NLRP6 may play an anti-inflammatory role in normal conjunctival tissue to maintain conjunctival homeostasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721221074200","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T07:35:21Z","timestamp":1643009721000},"page":"3058-3063","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["NLRP3 and NLRP6 expression in pterygium and normal conjunctiva and their relationship with pterygium formation and recurrence"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1340-1308","authenticated-orcid":false,"given":"Zhenfeng","family":"Guo","sequence":"first","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China"},{"name":"Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin, 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