{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:12:30Z","timestamp":1791267150510,"version":"4.1.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20190809100405621"],"award-info":[{"award-number":["JCYJ20190809100405621"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the plasma immune globulin and complement levels in different sorts of glaucoma to assess its association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Cohort study.<\/jats:italic>\n                      Plasma samples were collected from 226 normal controls and 236 glaucoma patients included 92 with acute primary angle-closure glaucoma (APACG), 76 with chronic primary angle-closure glaucoma (CPACG), 68 with primary open-angle glaucoma (POAG). 163 glaucoma patients with high intraocular pressure(IOP) was classified as a subgroup. Six indexes were analyzed: C3, C4, CH\n                      <jats:sub>50<\/jats:sub>\n                      , IgA, IgG, and IgM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a significant difference in C4, IgA, IgG, and IgM between patients with high IOP and normal controls groups(\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). TheC4 (0.27\u2009\u00b1\u20090.69 g\/L), IgA (3.11\u2009\u00b1\u20091.04 g\/L), IgG (12.07\u2009\u00b1\u20091.92 g\/L) and IgM (1.17\u2009\u00b1\u20090.49 g\/L) were higher(\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) in the high IOP groups compared with the normal controls (C4:0.25\u2009\u00b1\u20090.07 g\/L, IgA: 2.54\u2009\u00b1\u20091.07 g\/L, IgG: 11.21\u2009\u00b1\u20092.22 g\/L, IgM:0.99\u2009\u00b1\u20090.41 g\/L). There was a significant difference in age, C3, IgA, IgG, and IgM among the normal control, APACG, CPACG, and POAG. The C3 level in the APACG group (1.14\u2009\u00b1\u20090.16 g\/L) was higher than normal group (1.06\u2009\u00b1\u20090.18 g\/L). The IgA level was lower(P\u2009&lt;\u20090.05) in the normal group (2.54\u2009\u00b1\u20091.07 g\/L) compared with APACG (3.16\u2009\u00b1\u20090.97 g\/L) and POAG group (2.91\u2009\u00b1\u20091.11 g\/L). The IgG level of normal controls (11.21\u2009\u00b1\u20092.22 g\/L) was lower (P\u2009&lt;\u20090.05) than APACG group (12.15\u2009\u00b1\u20092.02 g\/L) and CPACG group (11.95\u2009\u00b1\u20092.28 g\/L). The IgM level was lower(P\u2009&lt;\u20090.05) in the normal group (0.99\u2009\u00b1\u20090.41 g\/L) compared with the APACG (1.24\u2009\u00b1\u20090.66 g\/L) and CPACG group (1.17\u2009\u00b1\u20090.45 g\/L).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The levels of the plasma expression of C3, IgA, IgG, IgM may be useful for discriminating the glaucoma patients and for assessing the progress of glaucoma in different sorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721221074202","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T09:10:55Z","timestamp":1643361055000},"page":"2907-2912","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Detection of plasma complement and immune globulin in different sorts of 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