{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:07:12Z","timestamp":1789589232909,"version":"build-2803163510"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate choroidal vascularity index (CVI) in patients developing mitogen-activated protein kinase kinase (MEK) inhibitor-associated retinopathy (MEKAR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective observational study, extensive ophthalmic examination was performed, including enhanced-depth-imaging-optical coherence tomography (EDI-OCT). EDI-OCT scans of patients receiving Cobimetinib, taken at baseline and at MEKAR manifestation, were considered for choroid analysis. Choroidal thickness (CT) was measured on high-resolution b-scans passing through the fovea at three different locations. Same scans were therefore imported for binarization into a previously reported software and CVI was calculated as the ratio of luminal area (LA) to total choroid area (TCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>When compared to baseline, eyes with MEKAR (14 eyes) did not show significative CT variation in subfoveal region (p\u2009=\u20090,57), 750-\u00b5m-nasal to the fovea (p\u2009=\u20090,08) and 750-\u00b5m-temporal to the fovea (p\u2009=\u20090,07). Similarly, there were no statistically significant differences for TCA (p\u2009=\u20090.54), LA (p\u2009=\u20090.85), stromal area (SA) (p\u2009=\u20090.13), LA\/SA (p\u2009=\u20090.34) and CVI (p\u2009=\u20090.47). Best-corrected visual acuity was significantly reduced at fluid accumulation when compared to baseline values (p\u2009=\u20090.03), with complete recovery after fluid resolution (p\u2009=\u20090.73).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Multiple parameters reflecting the status of the choroid seemed not influenced by Cobimetinib administration. Retinal pigment epithelium toxic disfunction likely represents the crucial step in MEKAR pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721221081471","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T08:48:38Z","timestamp":1645606118000},"page":"3564-3573","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Choroidal vasculature analysis in MEK inhibitor-associated retinopathy"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-0639","authenticated-orcid":false,"given":"Alessio","family":"Cerquaglia","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, Section of Ophthalmology, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6817-2488","authenticated-orcid":false,"given":"Marco","family":"Lupidi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Section of Ophthalmology, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-5343","authenticated-orcid":false,"given":"Jay","family":"Chhablani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramkailash","family":"Gujar","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Section of Ophthalmology, University of Perugia, Perugia, 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