{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:26:36Z","timestamp":1790483196908,"version":"4.1.0"},"reference-count":109,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sj\u00f6gren's syndrome is an autoimmune disease, and its important feature is the lymphocyte infiltration of exocrine glands, including lacrimal glands. It contributes to defects of their activity and causes that one of the main manifestation of Sj\u00f6gren's syndrome is dry eye. Unfortunately, the discrimination between dry eye related and non-related to Sj\u00f6gren's syndrome is difficult at the initial stages of diseases. In addition, the available agents for the treatment of Sj\u00f6gren's syndrome-related dry eye have limited efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The purpose of this study was to describe and emphasize differences between Sj\u00f6gren's Syndrome-related dry eye and non-Sj\u00f6gren's Syndrome-related dry eye together with the determination of novel therapeutic options for Sj\u00f6gren's Syndrome-related dry eye.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A review of the relevant papers describing characteristics of Sj\u00f6gren's Syndrome-related dry eye and its therapy was conducted. This article is based on both pre-clinical and clinical evidences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>On the basis of our analysis, we indicated differences between Sj\u00f6gren's Syndrome-related dry eye and non-Sj\u00f6gren's Syndrome-related dry eye. Moreover, there are some novel markers that could be used in the diagnosis of Sj\u00f6gren's Syndrome-related dry eye. In addition, expect artificial tear, other agents e.g. hydroxychloroquine can be effective in therapy of disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sj\u00f6gren's Syndrome-related dry eye is a disorder, whose diagnosis may be difficult and mistaken for non-Sj\u00f6gren's Syndrome-related dry eye. However, Sj\u00f6gren's Syndrome-related dry eye has some specific features. In addition, the development of newer and safer therapeutic agents for Sj\u00f6gren's syndrome-related dry eye is needed, and therefore further clinical, randomized studies are necessary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721221091375","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T01:47:15Z","timestamp":1648691235000},"page":"3174-3184","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["Dry eye in Sj\u00f6gren's syndrome \u2013 characteristics and therapy"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3894-3990","authenticated-orcid":false,"given":"Mi\u0142osz","family":"Caban","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Medical University Barlicki Hospital \rNo. 1, Medical University of Lodz, Lodz, 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