{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:42:15Z","timestamp":1777581735025,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To study the different types and frequency of pseudoretinoblastoma (pseudoRB) lesions who present to a retinoblastoma centre due to concern that the condition may be retinoblastoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective chart review of 341 patients presenting sporadically to the Royal London Hospital from January 2009 to December 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>220 patients (65%) were confirmed to have retinoblastoma, while 121 (35%) had pseudoRB. There were 23 differential diagnoses in total. The top 3 differential diagnoses were Coats\u2019 disease (34%), Persistent Foetal Vasculature (PFV) (17%) and Combined Hamartoma of Retina and Retinal Pigment Epithelium (CHR-RPE) (13%). PseudoRBs differed with age at presentation. Under the age of 1 (n\u2009=\u200942), the most likely pseudoRB conditions were PFV (36%), Coats\u2019 disease (17%) and CHR-RPE (12%). These conditions were also the most common simulating conditions between the ages of 1 and 2 (n\u2009=\u200921), but Coats\u2019 disease was the most common in this age group (52%), followed by CHR-RPE (19%) and PFV (14%). Between the ages of 2 and 5 (n\u2009=\u200932), Coats\u2019 disease remained the most common (44%) pseudoRB lesion followed by CHR-RPE (13%), or PFV, Retinal Astrocytic Hamartoma (RAH), familial exudative vitreoretinopathy (FEVR) (all 6.3%). Over the age of 5 (n\u2009=\u200926), pseudoRBs were most likely to be Coats\u2019 disease (35%), RAH (12%), Uveitis, CHR-RPE, FEVR (all 7.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>35% of suspected retinoblastoma cases are pseudoRB conditions. Overall, Coats\u2019 disease is the most common pseudoRB condition, followed by PFV. Hamartomas (CHR-RPE &amp; RAH) are more prevalent in this cohort, reflecting improvements in diagnostic accuracy from referring ophthalmologists.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721221093190","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T01:03:31Z","timestamp":1651194211000},"page":"129-135","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Changing trends in pseudoretinoblastoma diagnoses: A 10 year review from the United Kingdom"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7446-0769","authenticated-orcid":false,"given":"Vinay","family":"Badhwar","sequence":"first","affiliation":[{"name":"Retinoblastoma Service, Royal London Hospital, Barts Health NHS Trust, London, UK"},{"name":"Northampton General Hospital NHS Trust, Northampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8601-7000","authenticated-orcid":false,"given":"Damien CM","family":"Yeo","sequence":"additional","affiliation":[{"name":"Retinoblastoma Service, Royal London Hospital, Barts Health NHS Trust, London, UK"},{"name":"Department of Ophthalmology, Alder Hey Children's Hospital, Alder Hey NHS Foundation Trust, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samruddhi","family":"Joshi","sequence":"additional","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Clifton","sequence":"additional","affiliation":[{"name":"Retinoblastoma Service, Royal London Hospital, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxine","family":"Fraser","sequence":"additional","affiliation":[{"name":"Retinoblastoma Service, Royal London Hospital, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zishan","family":"Naeem","sequence":"additional","affiliation":[{"name":"Retinoblastoma Service, Royal London Hospital, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1530-3824","authenticated-orcid":false,"given":"Mandeep S.","family":"Sagoo","sequence":"additional","affiliation":[{"name":"Retinoblastoma Service, Royal London Hospital, Barts Health NHS Trust, London, UK"},{"name":"NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and UCL Institute of Ophthalmology, City Road, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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