{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:42:43Z","timestamp":1777581763479,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To evaluate the effectiveness of epithelium-off (epi-off) accelerated corneal crosslinking (A-CXL, 9\u2005mW\/cm\n                      <jats:sup>2<\/jats:sup>\n                      , 10\u2005min) in adult keratoconus (KC) patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 151 KC corneas (124 patients) after A-CXL. The parameters best corrected visual acuity (BCVA) and the tomographic readings (Pentacam HR, Oculus, Germany) were analysed at 24, 12 and 6 months preoperatively, prior to surgery; and 6 weeks, 6 months, 1, 2 and &gt;2 years postoperatively. The demarcation line was assessed by anterior segment optical coherence tomography (Tomey SS-1000, CASIA 2 (Tomey, Nagoya, Japan)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Comparing pre- to postoperative findings 6 weeks after A-CXL with paired t-test, the anterior steep (46.8\u2009\u00b1\u20094.0|47.1\u2009\u00b1\u20094.1), flat (50.2\u2009\u00b1\u20094.3|50.6\u2009\u00b1\u20094.6) and maximal keratometry (57.6\u2009\u00b1\u20096.8|58.3\u2009\u00b1\u20096.8) increased (p\u2009&lt;\u20090.05), while the thinnest pachymetry decreased significantly (459\u2009\u00b1\u200939|444\u2009\u00b1\u200942, p\u2009&lt;\u20090.05). Lateron, however, there was a decreasing anterior flat (1, 2 and &gt;2 years; p\u2009&lt;\u20090.0001), mean (1 year; p\u2009=\u20090.01 and 2 years; p\u2009=\u20090.03) and maximal keratometry (1, 2 and &gt;2 years; p\u2009&lt;\u20090.0001). The posterior corneal keratometry readings did not change significantly until &gt;2 years after A-CXL (MANOVA; steep, p\u2009=\u20090.008; flat, p\u2009=\u20090.027; mean, p\u2009=\u20090.007). The mean depth of the demarcation line was 242\u2009\u00b1\u200962\u2005\u00b5m (53.6%). The preoperative logMAR BCVA (0.35\u2009\u00b1\u20090.02) decreased 6 weeks after A-CXL (0.39\u2009\u00b1\u20090.03) followed by a continuous improvement until the latest follow-up (0.18\u2009\u00b1\u20090.04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A-CXL constitutes a successful method for KC stabilization. Signs of KC progression occur within the first 6 weeks postoperatively (\u201cpseudoprogression\u201d), but this is not indicative of the long-term effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721221099257","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T02:24:33Z","timestamp":1652149473000},"page":"2565-2576","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Accelerated corneal crosslinking causes pseudoprogression in keratoconus within the first 6 weeks without affecting posterior corneal curvature"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9181-8913","authenticated-orcid":false,"given":"Kassandra","family":"Xanthopoulou","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Saarland University Medical Center, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Milioti","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Saarland University Medical Center, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loay","family":"Daas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Saarland University Medical Center, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Saarland University Medical Center, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9701-8204","authenticated-orcid":false,"given":"Berthold","family":"Seitz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Saarland University Medical Center, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Flockerzi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Saarland University Medical Center, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2017.06.009"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)00119-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1517\/21678707.2013.765799"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.jcrs.0000000000000435"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12211"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-108653"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2010.04.006"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874364101711010225"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yaoo.2017.03.021"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12571"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.05.019"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-3966-0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.10.060"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13748"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-019-0141-6"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11409"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4745101"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.4274\/balkanmedj.galenos.2020.2019.8.45"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-3955-3"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-316789"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.01.012"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.09.033"},{"key":"e_1_3_3_25_2","first-page":"67","article-title":"Accelerated versus conventional corneal collagen cross-linking in patients with keratoconus: an intrapatient comparative study","volume":"38","author":"Sadoughi MM","year":"2018","unstructured":"Sadoughi MM, Einollahi B, Baradaran-Rafii A, et al. 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