{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:42:50Z","timestamp":1777581770696,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100022607","name":"Elsemay Bj\u00f6rn Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100022607","id-type":"DOI","asserted-by":"crossref"}]},{"name":"P\u00e4ij\u00e4t-H\u00e4me Joint Authority for Health and Wellbeing"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report the unforeseen complication of total obstruction of a glaucoma drainage implant (GDI) tube lumen by white deposit material and to present a preliminary report identifying the composition of this material.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two subjects with a high IOP due to total obstruction of a GDI tube were reviewed. Both patients had a long history with brinzolamide and timolol maleate eye drops. The GDI tube was swept with a 5-0 polypropylene suture stent in order to open the tube. The intraluminal solid sample was successfully collected from the implant tube in one patient. High-performance liquid chromatography-mass spectrometry (HPLC-MS) was used to determine the origin of the intraluminal sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Intraluminal deposits containing components of antiglaucoma drugs e.g., timolol and brinzolamide are a rare cause of total obstruction of GDI tubes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study describes a new cause of total obstruction GDI tubes. The long-term use of timolol maleate and brinzolamide and their presence in the intraluminal solid sample collected from the blocked GDI tube suggest that the glaucoma medication may have a role in the pathogenesis. However, the exact mechanism is unknown and requires further studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721221100074","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T18:22:09Z","timestamp":1652898129000},"page":"307-311","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Intraluminal deposits: A rare cause of glaucoma drainage implant total obstruction"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0808-2250","authenticated-orcid":false,"given":"Juha","family":"V\u00e4lim\u00e4ki","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, PHHYKY, Lahti, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveena","family":"Nukareddy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu","family":"Uusitalo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"},{"name":"Tays Eye Centre, Tampere University Hospital, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla","family":"Aapola","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"bibr1-11206721221100074","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.10.002"},{"key":"bibr2-11206721221100074","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/167564"},{"key":"bibr3-11206721221100074","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.10.024"},{"key":"bibr4-11206721221100074","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199400310-00014"},{"key":"bibr5-11206721221100074","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2012.04.004"},{"key":"bibr6-11206721221100074","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000840"},{"key":"bibr7-11206721221100074","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2018.02.057"},{"key":"bibr8-11206721221100074","doi-asserted-by":"publisher","DOI":"10.1002\/jms.3468"},{"key":"bibr9-11206721221100074","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.10.025"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721221100074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721221100074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721221100074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:46:31Z","timestamp":1777405591000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721221100074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,16]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1177\/11206721221100074"],"URL":"https:\/\/doi.org\/10.1177\/11206721221100074","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,16]]}}}