{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:33:21Z","timestamp":1777581201098,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T00:00:00Z","timestamp":1662249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report three cases of ocular myositis and scleritis, bilateral scleritis and unilateral single muscle myositis after mRNA COVID-19 vaccination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Case series of three patients who presented to the Orbit Outpatient Service of Fondazione Policlinico Universitario A. Gemelli with a history of unilateral proptosis, diplopia and pain, bilateral red eye and pain during eye movements and unilateral proptosis and inconstant diplopia respectively with onset 5\u201310 days after m-RNA COVID-19 vaccine. A thorough hematologic work up and orbital contrast enhanced magnetic resonance imaging (MRI) in patients with proptosis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients were females, 64, 58 and 45 years old respectively. MRI showed enlargement of all right rectus muscles, with both muscle belly and insertion involvement in the first case associated to right scleritis. A bilateral scleritis was diagnosed in the second patient and a single muscle myositis in the third patient. Serological tests excluded thyroid diseases. The first and second patient were treated respectively with oral and topical glucorticoids with a complete clinical response. Two 2 cycles of oral non-steroidal anti-inflammatory drugs were administered to the third patient with a partial response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>As far as we know these are the first report of orbital myositis and scleritis presenting after mRNA BNT162b2 vaccine (Pfizer\/BioNTech) and mRNA-1273-(Moderna) vaccine, an uncommon effect of a likely autoimmune reaction triggered by the virus antigen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721221123780","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T02:14:07Z","timestamp":1662344047000},"page":"NP29-NP34","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Orbital myositis and scleritis after anti-SARS-CoV-2 mRNA vaccines: A report of three cases"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9993-5986","authenticated-orcid":false,"given":"Gustavo","family":"Savino","sequence":"first","affiliation":[{"name":"Ophthalmology Unit, \u201cFondazione Policlinico Universitario A. Gemelli IRCCS\u201d, Rome, Italy"},{"name":"Catholic University \u201cSacro Cuore\u201d, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9500-049X","authenticated-orcid":false,"given":"Gloria","family":"Gambini","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, \u201cFondazione Policlinico Universitario A. Gemelli IRCCS\u201d, Rome, Italy"},{"name":"Catholic University \u201cSacro Cuore\u201d, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Scorcia","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Magna Gr\u00e6cia University, Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolino","family":"Comi","sequence":"additional","affiliation":[{"name":"Azienda Ospadaliera Universitaria Mater Domini, Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Fossataro","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, \u201cFondazione Policlinico Universitario A. Gemelli IRCCS\u201d, Rome, Italy"},{"name":"Catholic University \u201cSacro Cuore\u201d, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Stanislao Rizzo","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, \u201cFondazione Policlinico Universitario A. Gemelli IRCCS\u201d, Rome, Italy"},{"name":"Catholic University \u201cSacro Cuore\u201d, Rome, Italy"},{"name":"Department of Ophthalmology, Magna Gr\u00e6cia University, Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,4]]},"reference":[{"key":"bibr1-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000001429"},{"key":"bibr2-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2021.04.002"},{"key":"bibr3-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1080\/01676830.2021.1962366"},{"key":"bibr4-11206721221123780","first-page":"1","author":"Mangan MS","journal-title":"Ocul Immunol Inflamm"},{"key":"bibr5-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000001517"},{"key":"bibr6-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000001847"},{"key":"bibr7-11206721221123780","first-page":"1","author":"Ng XL","journal-title":"Ocul Immunol Inflamm"},{"key":"bibr8-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14484"},{"key":"bibr9-11206721221123780","unstructured":"Feizi S. Anterior Scleritis Manifesting after coronavirus disease 2019: a report of two cases."},{"key":"bibr10-11206721221123780","unstructured":"Basak Bostanci C. Ocular manifestations of coronavirus disease 2019."},{"key":"bibr11-11206721221123780","unstructured":"Pichi F. Shaikha Aljneibi Association of Ocular Adverse events with inactivated COVID-19 Vaccination in patients in Abu Dhabi."},{"key":"bibr12-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(99)00101-0"},{"key":"bibr13-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000001533"},{"key":"bibr14-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000001429"},{"key":"bibr15-11206721221123780","unstructured":"Ochani R, Asad A, Yasmin F, Shaikh S et al. COVID-19 pandemic: from origins to outcomes. A comprehensive review of viral pathogenesis, clinical manifestations, diagnostic evaluation, and management.\n                      Infez Med\n                      2021; 29(1): 20\u201336."},{"key":"bibr16-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002643"},{"key":"bibr17-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1080\/01676830.2020.1768560"},{"key":"bibr18-11206721221123780","first-page":"1","author":"Mart\u00ednez D\u00edaz M","journal-title":"Orbit"},{"key":"bibr19-11206721221123780","author":"Dinkin M","journal-title":"J Neuroophthalmol"},{"key":"bibr20-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-020-01516-2"},{"key":"bibr21-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102506"},{"key":"bibr22-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316686406"},{"key":"bibr23-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102524"},{"key":"bibr24-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.056135"},{"key":"bibr25-11206721221123780","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcab090"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721221123780","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721221123780","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721221123780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:44:12Z","timestamp":1777405452000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/11206721221123780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,4]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1177\/11206721221123780"],"URL":"https:\/\/doi.org\/10.1177\/11206721221123780","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,4]]}}}