{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:34:12Z","timestamp":1777581252013,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T00:00:00Z","timestamp":1667088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81000265"],"award-info":[{"award-number":["81000265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671504"],"award-info":[{"award-number":["81671504"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2021YFC2701700"],"award-info":[{"award-number":["2021YFC2701700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the incidence, clinical characteristics and short-term prognosis of retinal hemorrhage (RH) in premature infants with retinopathy of prematurity (ROP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From July 2015 to December 2021, the incidence and clinical characteristics of RH in premature infants with ROP diagnosed in a NICU of China before treatment were retrospectively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 670 premature infants were diagnosed with ROP, including 406 males and 254 females, with a mean gestational age (GA) of 29.51\u2009\u00b1\u20092.15w and a mean birth weight of 1240.56\u2009\u00b1\u2009292.97g, excluding 10 premature infants who had progressed to stage 4 or 5 at the time of transfer and receiving vitrectomy. Of them, 322 (48.8%) premature infants had Type 1 ROP and received laser or anti-VEGF therapy, and 142 (21.3%) premature infants developed RH before treatment. The GA and birth weight of RH group were lower than those of non-RH group (29.19\u2009\u00b1\u20092.19w vs. 29.60\u2009\u00b1\u20092.13w; 1178.11\u2009\u00b1\u2009282.01g vs. 1257.69\u2009\u00b1\u2009293.85g, both P\u2009&lt;\u20090.05), and the proportion of premature infants receiving treatment was also higher than that of non-RH group (97\/142, 68.3% vs. 225\/518, 43.4%). The lower the GA and the birth weight, the higher the incidence of RH. The incidence of RH was 45.5% in GA &lt;26w and 30.5% in birth weight &lt;1000g. After treatment, 7 eyes (2.6%) of 5 cases (3.5%) in RH group developed retinal detachment vs. 4 eyes (0.4%) of 3 cases (0.6%) in non-RH group, showing a significant difference between the two groups (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20098.043, P\u2009&lt;\u20090.01). Regression analysis showed that RH, Zone I lesions, plus lesions, and the postnatal time of ocular lesions were independent risk factors for Type 1 ROP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The lower the GA and the birth weight, the higher the incidence of ROP complicated with RH. RH is an indicator of severe ROP associated with poor retinal prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721221136314","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T02:21:46Z","timestamp":1667182906000},"page":"1084-1089","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical characteristics, risk factors and short-term prognosis of retinopathy of prematurity complicated with retinal hemorrhage"],"prefix":"10.1177","volume":"33","author":[{"given":"Qiuping","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neonatology, Senior Department of Pediatrics, the Seventh Medical Center of PLA General Hospital, Beijing, China"},{"name":"National Engineering Laboratory for Birth defects prevention and control of key technology, Beijing, China"},{"name":"Beijing Key Laboratory of Pediatric Organ Failure, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Senior Department of Pediatrics, the Seventh Medical Center of PLA General Hospital, Beijing, China"},{"name":"National Engineering Laboratory for Birth defects prevention and control of key technology, Beijing, China"},{"name":"Beijing Key Laboratory of Pediatric Organ Failure, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zonghua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, the Seventh Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Senior Department of Pediatrics, the Seventh Medical Center of PLA General Hospital, Beijing, China"},{"name":"National Engineering Laboratory for Birth defects prevention and control of key technology, Beijing, China"},{"name":"Beijing Key Laboratory of Pediatric Organ Failure, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2634-0292","authenticated-orcid":false,"given":"Zhichun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Senior Department of Pediatrics, the Seventh Medical Center of PLA General Hospital, Beijing, China"},{"name":"National Engineering Laboratory for Birth defects prevention and control of key technology, Beijing, China"},{"name":"Beijing Key Laboratory of Pediatric Organ Failure, Beijing, 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