{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:34:55Z","timestamp":1777581295636,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract Purpose<\/jats:title>\n                    <jats:p>To highlight similarities between the cross-sectional retinal lesion appearance in a patient with punctate inner choroidopathy (PIC), Ebola virus disease (EVD) retinopathy and the von Szily mouse model of herpes simplex virus type 1 (HSV) retinopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Case report and cross-sectional retinal lesion comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Whilst phenotypically different on colour imaging, a near-identical lesion appearance on optical coherence tomography, characterised by a focal photoreceptor loss and distinctive V-shaped collapse of the overlying retinal layers, was observed in both PIC and EVD retinopathy. This mirrored the early histological appearance of the neuronally transmitted HSV retinopathy in a mouse model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Given the occurrence of this phenotypic appearance has been demonstrated in an animal model where the viral pathophysiological mechanism is known, together with its observation in EVD retinopathy with a shared, hypothesised neurotropic retinal pathogenesis, the potential of a common pathophysiology accounting for the appearance in PIC lesions is a possibility which may provide a potential avenue for future research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721221144337","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T04:22:30Z","timestamp":1670818950000},"page":"NP148-NP149","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Similarities in the histological mouse model of early herpes simplex retinopathy with punctate inner choroidopathy and Ebola virus disease retinopathy"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7323-1681","authenticated-orcid":false,"given":"Paul J","family":"Steptoe","sequence":"first","affiliation":[{"name":"Princess Alexandra Eye Pavilion, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine M","family":"Guly","sequence":"additional","affiliation":[{"name":"Princess Alexandra Eye Pavilion, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D","family":"Dick","sequence":"additional","affiliation":[{"name":"Princess Alexandra Eye Pavilion, Edinburgh, UK"},{"name":"Bristol Eye Hospital, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK"},{"name":"Bristol Medical School, University of Bristol, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"bibr1-11206721221144337","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(84)90243-5"},{"key":"bibr2-11206721221144337","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2016.10.003"},{"key":"bibr3-11206721221144337","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2018.1248"},{"key":"bibr4-11206721221144337","first-page":"1181","volume":"28","author":"Holland GN","year":"1987","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr5-11206721221144337","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-020-01389-2"},{"key":"bibr6-11206721221144337","first-page":"1883","volume":"32","author":"Robbins SG","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr7-11206721221144337","doi-asserted-by":"publisher","DOI":"10.3389\/fopht.2021.802962"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721221144337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721221144337","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721221144337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:44:38Z","timestamp":1777405478000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/11206721221144337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,12]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1177\/11206721221144337"],"URL":"https:\/\/doi.org\/10.1177\/11206721221144337","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,12]]}}}