{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:35:00Z","timestamp":1777581300039,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report a case of a Henle fiber layer hemorrhage as the initial manifestation of Factor V Leiden disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Case report and literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A healthy 19-year-old patient presented with a spontaneous Henle fiber layer (HFL) hemorrhage. The genetic analysis showed a previously unknown homozygous Factor V Leiden Mutation. No specific treatment was given due to the patient's good visual acuity and favorable prognosis, but the diagnosis of a Factor V Leiden mutation enabled a correct therapeutic management to be followed by the patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Advances in eye imaging allow to detect ocular findings that may lead to an early diagnosis and treatment. To the best of our knowledge, this is the first case of a HFL hemorrhage as the initial manifestation of Factor V Leiden disease. Further research is needed to identify the pathways linking these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721231154294","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T01:16:36Z","timestamp":1675300596000},"page":"NP69-NP73","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Henle fiber layer hemorrhage as the first manifestation of factor V Leiden homozygous mutation"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5880-1594","authenticated-orcid":false,"given":"Ana","family":"Flores-M\u00e1rquez","sequence":"first","affiliation":[{"name":"Department of Ophtalmology, Hospital Costa del Sol, Marbella, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan \u00c1ngel","family":"Moreno-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Ophtalmology, Hospital Costa del Sol, Marbella, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Garc\u00eda-Marcet","sequence":"additional","affiliation":[{"name":"Department of Ophtalmology, Hospital Costa del Sol, Marbella, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8197-4602","authenticated-orcid":false,"given":"Fernando","family":"Garc\u00eda-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Ophtalmology, Hospital Costa del Sol, Marbella, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saturnino","family":"Gismero-Moreno","sequence":"additional","affiliation":[{"name":"Department of Ophtalmology, Hospital Costa del Sol, Marbella, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7464-2493","authenticated-orcid":false,"given":"Carlos","family":"Rocha-de-Lossada","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Regional Universitario, M\u00e1laga, Spain"},{"name":"Department of Surgery, Division of Ophthalmology, Faculty of Medicine, University of Sevilla, Sevilla, Spain"},{"name":"Department of Ophthalmology, Qvision, Vithas, Almer\u00eda, Spain"},{"name":"Department of Ophtalmology, Vithas, M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"bibr1-11206721231154294","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.7.883"},{"key":"bibr2-11206721231154294","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-315443"},{"key":"bibr3-11206721231154294","doi-asserted-by":"publisher","DOI":"10.1097\/01.moh.0000130315.41033.32"},{"key":"bibr4-11206721231154294","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20636"},{"key":"bibr5-11206721231154294","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.67069"},{"key":"bibr6-11206721231154294","first-page":"978","volume":"117","author":"Dhar-Munshi S","year":"1999","journal-title":"Arch Ophthalmol"},{"key":"bibr7-11206721231154294","doi-asserted-by":"publisher","DOI":"10.1159\/000442788"},{"key":"bibr8-11206721231154294","doi-asserted-by":"publisher","DOI":"10.35841\/clinical-ophthalmology.2.1.38-40"},{"key":"bibr9-11206721231154294","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2020.100934"},{"key":"bibr10-11206721231154294","doi-asserted-by":"publisher","DOI":"10.1159\/000511373"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721231154294","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721231154294","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721231154294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:44:49Z","timestamp":1777405489000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/11206721231154294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,1]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1177\/11206721231154294"],"URL":"https:\/\/doi.org\/10.1177\/11206721231154294","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,1]]}}}