{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:48:58Z","timestamp":1787698138224,"version":"build-2784847793"},"reference-count":175,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>Glaucoma is an optic neuropathy characterized by death of retinal ganglion cells (RGCs), which leads to progressive visual field loss and may result in blindness. Currently, the only available treatment to avoid or delay progression in glaucoma patients is to decrease intraocular pressure (IOP). However, despite adequate IOP control, approximately 25% of the patients continue to progress. To delay or prevent optic nerve damage in glaucoma, two forms of vitamin B3, nicotinamide (NAM) and nicotinamide riboside (NR) are emerging as viable adjuvant therapies. These compounds are nicotinamide adenine dinucleotide (NAD) precursors. NAD is essential for proper cell functioning and is involved in several metabolic activities, including protection against reactive oxygen species, contribution to the performance of various enzymes, and maintenance of mitochondrial function. Due to its beneficial effects and to the evidence of the reduction of NAD bioavailability with aging, researchers are seeking ways to replenish the cellular NAD pool, by administrating its precursors (NAM and NR), believing that it will reduce the RGC vulnerability to external stressors, such as increased IOP. This article attempts to analyze the current knowledge regarding the use of NAM and NR for the prevention and\/or treatment of glaucoma.<\/jats:p>","DOI":"10.1177\/11206721231161101","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:23:45Z","timestamp":1678764225000},"page":"1801-1815","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["The use of Nicotinamide and Nicotinamide riboside as an adjunct therapy in the treatment of glaucoma"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9780-0535","authenticated-orcid":false,"given":"Samuel","family":"Goulart Nac\u00e1cio e Silva","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Lu\u00eds","family":"Occhiutto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vital Paulino","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"bibr1-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6509809"},{"key":"bibr2-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31469-1"},{"key":"bibr3-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70113-X"},{"key":"bibr4-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.05.025"},{"key":"bibr5-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"bibr6-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.10.053"},{"key":"bibr7-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.10.1268"},{"key":"bibr8-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00272-4"},{"key":"bibr9-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00538-9"},{"key":"bibr10-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-317406"},{"key":"bibr11-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62111-5"},{"key":"bibr12-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2011.11.002"},{"key":"bibr13-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2022.09.009"},{"key":"bibr14-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.1997.tb00391.x"},{"key":"bibr15-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1177\/112067219700700409"},{"key":"bibr16-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.8.1030"},{"key":"bibr17-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1208\/ps050325"},{"key":"bibr18-11206721231161101","doi-asserted-by":"publisher","DOI":"10.3390\/nu10030359"},{"key":"bibr19-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.01.022"},{"key":"bibr20-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.03.048"},{"key":"bibr21-11206721231161101","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666171109124520"},{"key":"bibr22-11206721231161101","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170705101910"},{"key":"bibr23-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2020.07.014"},{"key":"bibr24-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1177\/1120672120960337"},{"key":"bibr25-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2018.09.005"},{"key":"bibr26-11206721231161101","doi-asserted-by":"publisher","DOI":"10.2174\/1389201021666200130113441"},{"key":"bibr27-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2006.04.014"},{"key":"bibr28-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/68.5.1081"},{"key":"bibr29-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8259371"},{"key":"bibr30-11206721231161101","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103158"},{"key":"bibr31-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000767"},{"key":"bibr32-11206721231161101","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13060893"},{"key":"bibr33-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal0092"},{"key":"bibr34-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13818"},{"key":"bibr35-11206721231161101","doi-asserted-by":"publisher","DOI":"10.3390\/nu13124263"},{"key":"bibr36-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051536"},{"key":"bibr37-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1258\/jrsm.2008.08k010"},{"key":"bibr38-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1002\/9781119946045.ch19"},{"key":"bibr39-11206721231161101","unstructured":"Niacin - Health Professional Fact Sheet [Internet]. [cited 2021 Nov 20]. Available from: https:\/\/ods.od.nih.gov\/factsheets\/Niacin-HealthProfessional\/"},{"key":"bibr40-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12119"},{"key":"bibr41-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1177\/1178646918776658"},{"key":"bibr42-11206721231161101","first-page":"1555","volume-title":"Goodman & Gilman\u2019s the pharmacological basis of therapeutics","author":"Marcus R","year":"1996","edition":"9"},{"key":"bibr43-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2005.05.011"},{"key":"bibr44-11206721231161101","unstructured":"National Academies Press (US). Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. 1998."},{"key":"bibr45-11206721231161101","doi-asserted-by":"publisher","DOI":"10.3390\/molecules14093446"},{"key":"bibr46-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3203-08.2008"},{"key":"bibr47-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-0048-3"},{"key":"bibr48-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2015.08.012"},{"key":"bibr49-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06356.x"},{"key":"bibr50-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.7.1679"},{"key":"bibr51-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-019-1604-4"},{"key":"bibr52-11206721231161101","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.65.507"},{"key":"bibr53-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb02572.x"},{"key":"bibr54-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1983.01650340046018"},{"key":"bibr55-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb06222.x"},{"key":"bibr56-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.1998.00379.x"},{"key":"bibr57-11206721231161101","first-page":"13","volume":"8","author":"Starr P.","year":"2015","journal-title":"Am Health Drug Benefits"},{"key":"bibr58-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701058"},{"key":"bibr59-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690060083010"},{"key":"bibr60-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13021"},{"key":"bibr61-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0002hyp"},{"key":"bibr62-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20202856"},{"key":"bibr63-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1007\/BF00405010"},{"key":"bibr64-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.1996.9.5.501"},{"key":"bibr65-11206721231161101","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.6.980"},{"key":"bibr66-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00416-7"},{"key":"bibr67-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.03.024"},{"key":"bibr68-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.28.061807.155443"},{"key":"bibr69-11206721231161101","doi-asserted-by":"publisher","DOI":"10.3390\/biom9010034"},{"key":"bibr70-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12948"},{"key":"bibr71-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1038\/srep26933"},{"key":"bibr72-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.04.022"},{"key":"bibr73-11206721231161101","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061616"},{"key":"bibr74-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026099"},{"key":"bibr75-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700221RR"},{"key":"bibr76-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.12.005"},{"key":"bibr77-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00313-x"},{"key":"bibr78-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2014.04.002"},{"key":"bibr79-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0161-5"},{"key":"bibr80-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1042\/BST20180420"},{"key":"bibr81-11206721231161101","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100368"},{"key":"bibr82-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.023"},{"key":"bibr83-11206721231161101","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092871"},{"key":"bibr84-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-016-0224-3"},{"key":"bibr85-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)01005-4"},{"key":"bibr86-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1159\/000057762"},{"key":"bibr87-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1089\/10966200152053686"},{"key":"bibr88-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.93"},{"key":"bibr89-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9483h"},{"key":"bibr90-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02063-5"},{"key":"bibr91-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.10.47"},{"key":"bibr92-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2320-06.2006"},{"key":"bibr93-11206721231161101","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061402"},{"key":"bibr94-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(05)80042-6"},{"key":"bibr95-11206721231161101","first-page":"3460","volume":"41","author":"Quigley HA","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr96-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16257-0"},{"key":"bibr97-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3192"},{"key":"bibr98-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.7.906"},{"key":"bibr99-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100130295012"},{"key":"bibr100-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.7.917"},{"key":"bibr101-11206721231161101","first-page":"240","volume":"119","author":"Liu B","year":"2001","journal-title":"Archives of Ophthalmology [Internet]"},{"key":"bibr102-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3164734"},{"key":"bibr103-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1702486"},{"key":"bibr104-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.06.004"},{"key":"bibr105-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.05.010"},{"key":"bibr106-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2010.07.015"},{"key":"bibr107-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101988"},{"key":"bibr108-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4310469"},{"key":"bibr109-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1038\/35041687"},{"key":"bibr110-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2012.01.008"},{"key":"bibr111-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.01.014"},{"key":"bibr112-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0208"},{"key":"bibr113-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.03.025"},{"key":"bibr114-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.06.001"},{"key":"bibr115-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1989.tb01617.x"},{"key":"bibr116-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00114-1"},{"key":"bibr117-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.4.458"},{"key":"bibr118-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2005.11.001"},{"key":"bibr119-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108506"},{"key":"bibr120-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.09.008"},{"key":"bibr121-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2717"},{"key":"bibr122-11206721231161101","unstructured":"Mcelnea EM, Quill B, Docherty NG, et al. Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors [Internet]. 2011. Available from: http:\/\/www.molvis.org\/molvis\/v17\/a133"},{"key":"bibr123-11206721231161101","doi-asserted-by":"publisher","DOI":"10.3390\/nu12041189"},{"key":"bibr124-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070760"},{"key":"bibr125-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1639"},{"key":"bibr126-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140919"},{"key":"bibr127-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1661"},{"key":"bibr128-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.05.012"},{"key":"bibr129-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac4854"},{"key":"bibr130-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.11.003"},{"key":"bibr131-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.tma.2018.08.003"},{"key":"bibr132-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-27099"},{"key":"bibr133-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.11.020"},{"key":"bibr134-11206721231161101","first-page":"1765","volume":"62","author":"Petriti B","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr135-11206721231161101","doi-asserted-by":"publisher","DOI":"10.4161\/cam.3.1.7483"},{"key":"bibr136-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.009"},{"key":"bibr137-11206721231161101","doi-asserted-by":"publisher","DOI":"10.3390\/nu12071910"},{"key":"bibr138-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44646"},{"key":"bibr139-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523805225130"},{"key":"bibr140-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072282"},{"key":"bibr141-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200706181"},{"key":"bibr142-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2006.08.009"},{"key":"bibr143-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1080\/19420889.2017.1356956"},{"key":"bibr144-11206721231161101","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00232"},{"key":"bibr145-11206721231161101","first-page":"1","volume":"13","author":"Albanna W","year":"2019","journal-title":"PLoS One"},{"key":"bibr146-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2004.07.002"},{"key":"bibr147-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54930-4"},{"key":"bibr148-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6873"},{"key":"bibr149-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3947"},{"key":"bibr150-11206721231161101","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.3559"},{"key":"bibr151-11206721231161101","first-page":"2147","volume":"18","author":"Templeton JP","year":"2012","journal-title":"Mol Vis [Internet]"},{"key":"bibr152-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2021.4576"},{"key":"bibr153-11206721231161101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13063-021-05959-2","volume":"23","author":"Leung CKS","year":"2022","journal-title":"Trials"},{"key":"bibr154-11206721231161101","doi-asserted-by":"publisher","DOI":"10.3390\/biom10050687"},{"key":"bibr155-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(93)90133-S"},{"key":"bibr156-11206721231161101","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04211007"},{"key":"bibr157-11206721231161101","first-page":"58","volume":"31","author":"Shahbazian H","year":"2011","journal-title":"Nefrologia"},{"key":"bibr158-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15786-3"},{"key":"bibr159-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2012.00479.x"},{"key":"bibr160-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg703"},{"key":"bibr161-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2006.06.005"},{"key":"bibr162-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205670200"},{"key":"bibr163-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.07.016"},{"key":"bibr164-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197311292892208"},{"key":"bibr165-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2016.05.003"},{"key":"bibr166-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513004054"},{"key":"bibr167-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03421-7"},{"key":"bibr168-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqy132"},{"key":"bibr169-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186459"},{"key":"bibr170-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-019-01919-4"},{"key":"bibr171-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-017-0016-9"},{"key":"bibr172-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1177\/0960327115626254"},{"key":"bibr173-11206721231161101","unstructured":"GRAS Notice 635: Nicotinamide riboside chloride [Internet]. Available from: http:\/\/www.fda.gov\/Food\/IngredientsPackagingLabeling\/GRAS\/NoticeInventory\/default.htm"},{"key":"bibr174-11206721231161101","unstructured":"Crystalline Form of Nicotinamide Riboside."},{"key":"bibr175-11206721231161101","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46120-z"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721231161101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721231161101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721231161101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:44:57Z","timestamp":1777405497000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/11206721231161101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,14]]},"references-count":175,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1177\/11206721231161101"],"URL":"https:\/\/doi.org\/10.1177\/11206721231161101","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,14]]}}}