{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:50:02Z","timestamp":1789091402961,"version":"build-2803163510"},"reference-count":33,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate short-term peripapillary structural and vascular changes in DME after treatment with dexamethasone implant (DEX-I) and anti-VEGFs using OCT-A.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty-five patients with na\u00efve center-involving DME were enrolled. 33 of sixty five patients (group 1) underwent with single DEX-I 0.7\u2005mg (Ozurdex, Allergan, Inc., USA), 32 of sixty-five (group 2) underwent with intravitreal injection of aflibercept 0.5\u2005mg (Eylea, Bayer, Genentech, San Francisco, USA). The OCT acquisition was completed at the following visits: (i) \u201cT1 visit\u201d corresponding to the intravitreal injection of DEX-I or aflibercept in patients with na\u00efve center-involving DME (ii) \u201cT2 visit\u201d corresponding to the examination performed 2 weeks after intravitreal injection of aflibercept and 1 month after DEX-I. The parameters analyzed were: (i) RPC vasculature density (VD); (ii) peripapillary retinal nerve fiber layer (pRNFL) thickness, and (iii) intraocular pressure (IOP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The RPC analysis showed a VD increase at T2 in both groups, although values did not reach statistical significance (48.12\u00b1\u20094.17 and 49.04 \u00b1\u20094.23; P\u2009=\u20090.081 in Group 1 and 46.93\u00b1\u20093.16 and 47.17 \u00b1\u20093.70; P\u2009=\u20090.087 in Group 2). Likewise, the pRNFL thickness and IOP fluctuations did not show statistically significant changes in in both groups among the different study visits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>After intravitreal injection (anti-VEGF or DEX-I), no significant short-term changes were found in peripapillary microvasculature, IOP and pRNFL thickness in diabetic eyes treated with anti-VEGF or DEX-I.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721231163615","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T04:41:21Z","timestamp":1679287281000},"page":"2236-2242","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Short-term peripapillary structural and vascular changes following anti-VEGF vs. Dexamethasone intravitreal therapy in patients with DME"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0323-967X","authenticated-orcid":false,"given":"Pasquale","family":"Viggiano","sequence":"first","affiliation":[{"name":"Department of Translational Biomedicine Neuroscience, University of Bari \u201cAldo Moro\u201d, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-7910","authenticated-orcid":false,"given":"Maria Oliva","family":"Grassi","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine Neuroscience, University of Bari \u201cAldo Moro\u201d, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bisceglia","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine Neuroscience, University of Bari \u201cAldo Moro\u201d, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8768-899X","authenticated-orcid":false,"given":"Giacomo","family":"Boscia","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, A.O.U. 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