{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:10:34Z","timestamp":1784607034600,"version":"3.55.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To analyze the features of myopic macular schisis (MMS) in different retinal layers and to explore the role of M\u00fcller cells in the pathophysiology of such condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Spectral-domain optical coherence tomography (SD-OCT) images of myopic eyes with staphyloma and macular schisis were reviewed. The morphological features of MMS were analyzed and correlated with their geographical location in the parafoveal and perifoveal region. A biomechanical model was adopted to explain MMS morphological differences. The effect of the different schisis subtypes with best corrected visual acuity (BCVA) was also explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 36 eyes from 26 patients were included in this study. MMS was classified into inner, middle and outer retinal subtypes. The prevalence of middle retinal schisis was significantly lower in the parafovea, within a central 3 mm-diameter circle (p\u2009&lt;\u20090.001) centered at the fovea . The prevalence of inner retinal schisis was significantly higher outside the central 3-mm diameter circle, in the perifoveal region (p\u2009&lt;\u20090.001). No significant differences were noted in the prevalence of outer retinal schisis for these two locations (p\u2009=\u20090.475). The presence of middle retinal schisis within the central 3-mm diameter circle showed a weak association with lower BCVA (p\u2009=\u20090.058). The presence of outer retinal schisis within the central 3-mm diameter circle was significantly related with lower BCVA (p\u2009=\u20090.024).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Three major forms of MMS are distinguished: inner, middle and outer retinal schisis. This classification may have clinical importance as only the outer grade of schisis was associated with vision loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721231166164","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T01:09:22Z","timestamp":1681866562000},"page":"2250-2258","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Myopic macular schisis: Insights into distinct morphological subtypes and novel biomechanical hypothesis"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3364-2232","authenticated-orcid":false,"given":"Mayss","family":"Al-Sheikh","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2192-810X","authenticated-orcid":false,"given":"Andrea","family":"Govetto","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Circolo e Fondazione Macchi Hospital, ASST- Sette Laghi, Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nopasak","family":"Phasukkijwatana","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Matteucci","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Circolo e Fondazione Macchi Hospital, ASST- Sette Laghi, Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Repetto","sequence":"additional","affiliation":[{"name":"Department of Civil, Chemical and Environmental Engineering, University of Genoa, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario R","family":"Romano","sequence":"additional","affiliation":[{"name":"Humanitas University, Eye Unit, Humanitas-Gavazzeni Hospital, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Virgili","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Careggi University Hospital, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Zweifel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Barthelmes","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, 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