{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:53:25Z","timestamp":1784159605965,"version":"3.55.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To analyze the prescribing trends over a 7-years period, between 2013 and 2020, in a tertiary hospital (Hospital Clinico San Carlos, Madrid, Spain) and its health area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>A retrospective study on the data collected from the information systems, \u201cfarm@web\u201d and \u201cFarmadrid\u201d, of glaucoma prescriptions in the framework of a public health system (Spanish National Health System) during the last seven years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prostaglandin analogues were the most commonly used drugs in monotherapy during the study period (range: 36.82%\u2009\u2212\u200947.07%). Fixed combinations of topical hypotensives had an upward trend since 2013 (range: 39.99%\u2009\u2212\u200954.21%), becoming the most dispensed drugs in 2020 (48.99%). Preservative-free eye drops (lacking benzalkonium chloride, BAK) have displaced preservative containing topical treatments in all pharmacological groups. In 2013, BAK-preserved eye drops accounted for 91.1% of the total prescriptions, however in 2020 they only accounted for 34.2% of total prescriptions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of the present study highlight the current trend to avoid BAK-preserved eye drops for the treatment of glaucoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721231170034","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T02:29:31Z","timestamp":1681784971000},"page":"193-203","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Prescription trends for preservative free glaucoma medication in a public health system"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2339-3682","authenticated-orcid":false,"given":"Pilar","family":"P\u00e9rez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Ophthalmology Unit, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-6164","authenticated-orcid":false,"given":"B\u00e1rbara","family":"Burgos-Blasco","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6182-0753","authenticated-orcid":false,"given":"Laura","family":"Morales-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Fern\u00e1ndez-Ruiz-Mor\u00f3n","sequence":"additional","affiliation":[{"name":"Pharmacology Unit, Hospital Clinico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"G\u00f3mez-Calleja","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3577-6880","authenticated-orcid":false,"given":"Carlos","family":"Oribio-Quinto","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Collado-Vincueria","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Garcia-Feijoo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Oftalmol\u00f3gicas Ramon Castroviejo, Universidad Complutense de Madrid, Madrid, Spain"},{"name":"Cooperative Research Network on Age-Related Ocular Disease, and Visual and Life Quality, Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Ophthalmology Unit, Hospital Clinico San Carlos, Dept. of Ophthalmology and ORL, Faculty of Medicine, Universidad Complutense de Madrid, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9441-0542","authenticated-orcid":false,"given":"Jose Mar\u00eda","family":"Martinez-de-la-Casa","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid, Spain"},{"name":"Instituto de Investigaciones Oftalmol\u00f3gicas Ramon Castroviejo, Universidad Complutense de Madrid, Madrid, Spain"},{"name":"Ophthalmology Unit, Hospital Clinico San Carlos, Dept. of Ophthalmology and ORL, Faculty of Medicine, Universidad Complutense de Madrid, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"bibr1-11206721231170034","unstructured":"Levine ML, Brar S, Goldstein MH, et al. 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