{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:49:14Z","timestamp":1785440954023,"version":"3.56.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To report treatment methods and visual outcome of treating proliferative sickle cell retinopathy (PSCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective interventional.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Review of PSCR eyes treated between 2017 to 2022. Patient demographics, fundus findings at presentation, genotype, PSCR stage, treatment used, and visual outcome were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>108 eyes of 88 consecutive patients were studied. Male: Female 48:40. Mean age: 38.91 (SD:12.52) years. Genotype: sickle cell haemoglobin C (SC) 83 eyes (76.9%), sickle cell haemoglobin S (SS) 19 eyes (17.6%), and sickle cell trait (AS) 6 eyes (5.5%). PSCR stages: 3: 15 eyes (11.0%), 4: 74 eyes (67.0%), and 5: 19 eyes (22.0%). Treatment methods: Intravitreal Injection (IVI) of anti-vascular endothelial growth factor (VEGF) only (27 eyes,25%), scatter retinal laser photocoagulation (SRLP) only (7 eyes, 6.5%), Vitrectomy\u2009+\u2009SRLP (29 eyes, 26.9%), IVI\u2009+\u2009SRLP (25 eyes, 23.1%), and Vitrectomy\u2009+\u2009IVI\u2009+\u2009SRLP (20 eyes, 18.5%). The treatment used correlated with PSCR stage (p\u2009=\u20090.000). IVI only was mostly used to treat stage 4 (81.4%), and SRLP only was used for stages 3 (42.9%) and 5 (57.1%). IVI\u2009+\u2009SRLP treated eyes had the best pre- and post-treatment vision. Vitrectomy\u2009+\u2009SRLP treated eyes had the most improved vision. SRLP only had least visual improvement. Fundus findings correlated with visual outcome (p\u2009=\u20090.003); but stage of PSCR, genotype and treatment used had no correlation (P\u2009&gt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Several options effectively treat PSCR. Visual outcome improved or remained same in 90.7% of treated eyes. Randomized controlled trials will determine the optimum treatment for each distinct presentation of PSCR. Treatment guidelines and a disease classification system of prognostic value are unmet needs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721231199273","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T02:17:26Z","timestamp":1693966646000},"page":"558-565","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Visual outcome of treating proliferative sickle cell retinopathy in 108 eyes"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6805-2427","authenticated-orcid":false,"given":"Ogugua Ndubuisi","family":"Okonkwo","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Eye Foundation Retina Institute, Lagos, Nigeria"},{"name":"Department of Ophthalmology, Eye Foundation Hospital, Lagos, Nigeria"},{"name":"Department of Ophthalmology, Eye Foundation Hospital, Abuja, 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