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It has been proposed that controlling the translaminar pressure gradient at regular intervals may preserve the optic nerve and slow the course of glaucoma. The precisional modulation of this TLPG is a recently introduced concept that may play a role in the treatment of ophthalmic diseases such as glaucoma. In this manuscript, we review the applications of pressurized goggles on ophthalmic diseases. We also elaborate upon current investigations in modulation of the TLPG including goggles and the multi-pressure dial goggle. We discuss future research directions for ophthalmic diseases including spaceflight associated neuro-ocular syndrome (SANS), a large physiological barrier to future long-duration spaceflight.<\/jats:p>","DOI":"10.1177\/11206721231199779","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T02:18:27Z","timestamp":1693966707000},"page":"1328-1336","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Precisional modulation of translaminar pressure gradients for ophthalmic diseases"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8999-0212","authenticated-orcid":false,"given":"Ethan","family":"Waisberg","sequence":"first","affiliation":[{"name":"University College Dublin School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Ong","sequence":"additional","affiliation":[{"name":"Michigan Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouayad","family":"Masalkhi","sequence":"additional","affiliation":[{"name":"University College Dublin School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phani","family":"Paladugu","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA"},{"name":"Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA"},{"name":"The Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA"},{"name":"Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, New York, USA"},{"name":"Department of Ophthalmology, University of Texas Medical Branch, Galveston, TX, USA"},{"name":"University of Texas MD Anderson Cancer Center, Houston, TX, USA"},{"name":"Texas A&amp;M College of Medicine, Bryant, TX, USA"},{"name":"Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Berdahl","sequence":"additional","affiliation":[{"name":"Vance Thompson Vision, Sioux Falls, SD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.11686"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/EB.S272343"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40135-015-0067-7"},{"key":"e_1_3_2_5_2","article-title":"The diagnosis and treatment of glaucoma","author":"Schuster AK","year":"2020","unstructured":"Schuster AK, Erb C, Hoffmann EM, et al. 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