{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:59:50Z","timestamp":1780585190874,"version":"3.54.1"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report a case of exudative perifoveal exudative vascular anomalous complex (ePVAC) in a Brazilian healthy patient that underwent a complete resolution after aflibercept intravitreal injections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case description<\/jats:title>\n                    <jats:p>A 41-year-old healthy Brazilian man complained of acute central vision loss in his right eye (RE). Fundus examination showed a perifoveal hemorrhagic aneurysmal lesion, accompanied by several hard exudates in RE. On fluorescein angiography, these abnormalities showed a progressive hyperfluorescence with surrounding leakage. Optical coherence tomography (OCT) revealed a deep, perifoveal hyporeflective cystic space with a hyperreflective wall and hyperreflective material inside of fibrin-like aspect. Around this aneurism, intraretinal hyporeflective spaces suggestive of exudation were detected. Nor pathological flow signal, or telangiectatic dilations were evidenced on OCT-angiography. Therefore, a diagnosis of exudative ePVAC in RE was hypothesized. After an initial observation, the patient underwent three monthly aflibercept intravitreal injections (0.05\u2005ml\/2\u2005mg), with a significative anatomical and functional improvement after two weeks from first dose. On last follow-up at five months from baseline, patient experienced no evidence of new exudation and a stable visual acuity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Placental growth factor (PlGF) may impact on pericytes\u2019 dropout, and thus on ePVAC development. In contrast to the other anti-VEGF drugs, aflibercept is the only molecule contrasting PlGF. Therefore, aflibercept would act on ePVAC not as an anti-VEGF drug, but rather as an anti-PlGF one.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This report encouraged the use of aflibercept as a therapeutic option for ePVAC. Further studies are required to confirm our result and the impact of PlGF on ePVAC pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721231200116","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T03:56:53Z","timestamp":1693972613000},"page":"NP68-NP72","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["A Brazilian case of exudative perifoveal vascular anomalous complex responsive to aflibercept intravitreal injections"],"prefix":"10.1177","volume":"34","author":[{"given":"Eduardo","family":"Cunha de Souza","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hospital das Clinicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Tombolini","sequence":"additional","affiliation":[{"name":"School of Medicine, Vita-Salute San Raffaele University, Milan, Italy"},{"name":"Division of head and neck, Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2891-2012","authenticated-orcid":false,"given":"Riccardo","family":"Sacconi","sequence":"additional","affiliation":[{"name":"School of Medicine, Vita-Salute San Raffaele University, Milan, Italy"},{"name":"Division of head and neck, Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3238-9682","authenticated-orcid":false,"given":"Francesco","family":"Bandello","sequence":"additional","affiliation":[{"name":"School of Medicine, Vita-Salute San Raffaele University, Milan, Italy"},{"name":"Division of head and neck, Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-9581","authenticated-orcid":false,"given":"Giuseppe","family":"Querques","sequence":"additional","affiliation":[{"name":"School of Medicine, Vita-Salute San Raffaele University, Milan, Italy"},{"name":"Division of head and neck, Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"key":"bibr1-11206721231200116","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2011.03.002"},{"key":"bibr2-11206721231200116","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2020.04.025"},{"key":"bibr3-11206721231200116","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.10.009"},{"key":"bibr4-11206721231200116","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2019.1626450"},{"key":"bibr5-11206721231200116","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002435"},{"key":"bibr6-11206721231200116","doi-asserted-by":"publisher","DOI":"10.1159\/000526991"},{"key":"bibr7-11206721231200116","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002809"},{"key":"bibr8-11206721231200116","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-021-01889-0"},{"key":"bibr9-11206721231200116","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2022.101691"},{"key":"bibr10-11206721231200116","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100954"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721231200116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721231200116","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721231200116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:45:29Z","timestamp":1777405529000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/11206721231200116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,6]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1177\/11206721231200116"],"URL":"https:\/\/doi.org\/10.1177\/11206721231200116","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,6]]}}}