{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:36:55Z","timestamp":1777581415244,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report the emergence and progress of four late-stage characteristics: incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) and complete RPE and outer retinal atrophy (cRORA), drusen ooze and drusen collapse in eyes with dry age-related macular degeneration (AMD) using Spectral Domain Optical Coherence Tomography (SD-OCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective analysis of eyes with non-exudative AMD. Multimodal imaging was done at follow up visits\u2009\u2264\u200912 months. OCT volume scan was used to assess and identify the 4 characteristics. Univariate analysis was done for the various demographic and clinical characteristics.<\/jats:p>\n                    <jats:p>Patients with a mean age of 76.7\u2009\u00b1\u200910 years were followed up for 69.9\u2009\u00b1\u200920.6 months. iRORA, cRORA, drusen ooze was present in 15.6%, 15.6% and 15.6% of patients at baseline, respectively, and 25.0%, 40.6% and 53.1% of patients at the final follow-up, respectively. At baseline 9.1%, 0% and 9.1% of patients had bilateral drusen ooze, iRORA and cRORA, respectively. By the final follow-up, drusen collapse occurred in 46.9% and 18.8% patients in unilateral and bilateral eyes, respectively.<\/jats:p>\n                    <jats:p>For bilateral cases, the mean interval of time between emergence inthe two eyes for drusen ooze, drusen collapse, iRORA, and cRORA was 5\u2009\u00b1\u20091.4 years, 2.2\u2009\u00b1\u20092.2 years, 3.5\u2009\u00b1\u20090.7 and 1.7\u2009\u00b1\u20090.6 years, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Late-stage OCT biomarkers are seen bilaterally at 21.9% at baseline and at 56.3% at 5.8 years follow-up. Once present in one eye, cRORA had the shortest mean interval before appearance in the other eye.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721231204383","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:28:11Z","timestamp":1696318091000},"page":"683-690","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Bilateral evolution of OCT biomarkers in dry AMD: Long-term follow up study"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1994-9377","authenticated-orcid":false,"given":"Anindya","family":"Samanta","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Texas Tech University Health Sciences Center, Lubbock, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supriya","family":"Arora","sequence":"additional","affiliation":[{"name":"Bahamas Vision Center and Princess Margaret Hospital, Nassau, Bahamas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9969-3411","authenticated-orcid":false,"given":"Mahima","family":"Jhingan","sequence":"additional","affiliation":[{"name":"Jacobs Retina Center, University of California, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumit","family":"Singh","sequence":"additional","affiliation":[{"name":"Jacobs Retina Center, University of California, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohani","family":"Amarasekera","sequence":"additional","affiliation":[{"name":"UPMC Eye Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1907-7900","authenticated-orcid":false,"given":"Davide","family":"Tucci","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Surgical Sciences, Section of Ophthalmology, University of Perugia, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3812-9219","authenticated-orcid":false,"given":"Carlo","family":"Cagini","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Surgical Sciences, Section of Ophthalmology, University of Perugia, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6817-2488","authenticated-orcid":false,"given":"Marco","family":"Lupidi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Surgical Sciences, Section of Ophthalmology, University of Perugia, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-5343","authenticated-orcid":false,"given":"Jay","family":"Chhablani","sequence":"additional","affiliation":[{"name":"UPMC Eye Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309729"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.09.035"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.09.028"},{"key":"e_1_3_3_5_2","article-title":"Drusen Ooze: A Novel Hypothesis in Geographic Atrophy","author":"Mon\u00e9s J","unstructured":"Mon\u00e9s J, Garcia M, Biarn\u00e9s M, et al. Drusen Ooze: A Novel Hypothesis in Geographic Atrophy. Ophthalmol Retin. 2017;1(6):461-473. doi:https:\/\/doi.org\/10.1016\/j.oret.2017.02.006","journal-title":"Ophthalmol Retin."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19816"},{"key":"e_1_3_3_7_2","article-title":"Drusen ooze: Predictor for progression of dry age-related macular degeneration","author":"Jhingan M","unstructured":"Jhingan M, Singh SR, Samanta A, et al. Drusen ooze: Predictor for progression of dry age-related macular degeneration. Graefe\u2019s Arch Clin Exp Ophthalmol. 2021;259(9):2687-2694. doi:https:\/\/doi.org\/10.1007\/s00417-021-05147-7","journal-title":"Graefe\u2019s Arch Clin Exp Ophthalmol."},{"key":"e_1_3_3_8_2","article-title":"A simplified severity scale for age-related macular degeneration: AREDS report no. 18","author":"Ferris FL","year":"2005","unstructured":"Ferris FL, Davis MD, Clemons TE, et al. A simplified severity scale for age-related macular degeneration: AREDS report no. 18. Arch Ophthalmol. 2005;123(11):1570-1574.","journal-title":"Arch Ophthalmol."},{"key":"e_1_3_3_9_2","article-title":"Multimodal imaging patterns for development of central atrophy secondary to age-related macular degeneration","author":"Thiele S","unstructured":"Thiele S, Pfau M, Larsen PP, et al. Multimodal imaging patterns for development of central atrophy secondary to age-related macular degeneration. Investig Ophthalmol Vis Sci. 2018;59(4):AMD1-AMD11. doi:https:\/\/doi.org\/10.1167\/iovs.17-23315","journal-title":"Investig Ophthalmol Vis Sci."},{"key":"e_1_3_3_10_2","article-title":"Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16","author":"Keenan TD","unstructured":"Keenan TD, Agr\u00f3n E, Domalpally A, et al. Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16. Ophthalmology. 2018;125(12):1913-1928. doi:https:\/\/doi.org\/10.1016\/j.ophtha.2018.05.028","journal-title":"Ophthalmology"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2019.12.011"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721231204383","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721231204383","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721231204383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:45:34Z","timestamp":1777405534000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721231204383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,3]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1177\/11206721231204383"],"URL":"https:\/\/doi.org\/10.1177\/11206721231204383","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,3]]}}}