{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:37:31Z","timestamp":1777581451620,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Emerging evidence suggested a significant association between optic atrophy 1 (OPA1) polymorphisms and primary open angle glaucoma (POAG) risk. However, the current data are inconsistent or even contradictory. Given these, we conducted a meta-analysis to examine the precise association between OPA1 polymorphisms and POAG risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Online databases were retrieved, and the related studies were reviewed from inception to December 1, 2022. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated to examine the statistical power of each genetic model. In addition, heterogeneity, sensitivity, cumulative analysis, and publication bias were analyzed to guarantee statistical power.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Overall, 14 studies within 11 publications (involving 2,413 POAG patients and 1,904 controls) were included and some significant association between OPA1 rs166850 C\/T (T vs. C: OR\u2009=\u20091.24, 95%CI\u2009=\u20091.06\u20131.45,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01, I\n                      <jats:sup>2\u2009<\/jats:sup>\n                      =\u200939.0%; CT vs. CC: OR\u2009=\u20091.37, 95%CI\u2009=\u20091.05\u20131.79,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02, I\n                      <jats:sup>2\u2009<\/jats:sup>\n                      =\u200941.6%; CT\u2009+\u2009TT vs. CC: 1.37, 95%CI\u2009=\u20091.06\u20131.77,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02, I\n                      <jats:sup>2\u2009<\/jats:sup>\n                      =\u200941.6%), rs10451941T\/C (TC\u2009+\u2009CC vs. TT: OR\u2009=\u20091.79, 95%CI\u2009=\u20091.41\u20132.28,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01, I\n                      <jats:sup>2\u2009<\/jats:sup>\n                      =\u200971.9%) polymorphisms and POAG susceptibility. In addition, further significant associations were also observed in the stratified analysis, especially in normal tension glaucoma groups and Caucasian descendants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The observed evidences suggest that OPA1 polymorphisms may be associate with POAG susceptibility significantly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721231208244","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T23:51:07Z","timestamp":1698105067000},"page":"708-718","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between optic atrophy 1 polymorphisms and primary open angle glaucoma risk: Based on a meta-analysis"],"prefix":"10.1177","volume":"34","author":[{"given":"Yue-Feng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Yu","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Cai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Wudang Mountain Campus of Taihe Hospital Shiyan, Shiyan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Yang","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0298-300X","authenticated-orcid":false,"given":"Wei-Min","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"844","article-title":"Global data on visual impairment in the year 2002","volume":"82","author":"Resnikoff S","year":"2004","unstructured":"Resnikoff S, Pascolini D, Etya'ale D, et al. 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