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Oxidative damage is an important pathogenic factor in glaucoma, which triggers trabecular meshwork (TM) degeneration, which then leads to intraocular hypertension. Neurodegenerative insults during glaucomatous neurodegeneration initiate an immune response to restore tissue homeostasis. However, the oxidative stress (OS) that develops during the pathogenic processes of glaucoma, along with the agerelated OS, plays a critical role in shifting the physiological equilibrium. In the TM from glaucoma donors, proinflammatory markers were found, which were induced by the activation of a stress response. Chronic changes in the composition of antioxidants found in aqueous humour may induce alterations in TM as well as in the optic nerve head cells. Highlighting the pathogenic role of reactive oxygen species (ROS) in glaucoma has implications in preventing this disease. Various clinical trials are available to test the efficacy of antioxidant drugs in glaucoma management. In this review, we discuss the OS as a therapeutic target, suggesting that the modulation of a pro-oxidant\/antioxidant status might be a relevant target for glaucoma prevention and therapy.<\/jats:p>","DOI":"10.1177\/11206721231214297","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T03:19:58Z","timestamp":1700191198000},"page":"328-337","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Current trends in targeting the oxidative stress in glaucoma (Review)"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4089-1149","authenticated-orcid":false,"given":"Raluca Eugenia","family":"Iorga","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, \u201cGrigore T. 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