{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:37:40Z","timestamp":1793648260168,"version":"4.5.1"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Boiron","award":["1"],"award-info":[{"award-number":["1"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of a homeopathic eye drop medicinal product (Homeoptic\u00ae) with 0.9% sodium hydrochloride eye drops (Larmabak\u00ae) in patients with mild-to-moderate dry eye disease (DED).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, single-masked, observer-blinded, multicentre study on adult patients. Non-inferiority primary endpoint of the relative change between treatment groups in a composite Visual Analogue Scale (VAS) score covering five symptoms of DED, namely pain, itching, sensation of dry eye, impression of foreign body presence and burning, after 30 days of treatment. Details of all Adverse Events (AEs) were recorded and analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety three patients were randomised to each treatment arm. At Day 30, the mean VAS symptom score was 26.0\u2009\u00b1\u200918.8 in the Homeoptic\u00ae group and 32.8\u2009\u00b1\u200921.2 Larmabak\u00ae group. Homeoptic\u00ae was demonstrated to be non-inferior to Larmabak\u00ae: the mean treatment difference of \u22127 being below the 10\u2005mm upper limit of the 95% CI ([-12.9; \u22121.0]) pre-set as significant. The superiority of Homeoptic\u00ae over Larmabak\u00ae was then established with detection of a significant difference between the two treatment groups (p\u2009=\u20090.022). Significant differences between the treatment groups in favour of Homeoptic\u00ae were also detected in isolated VAS scores for the symptoms dry eye sensation ( p\u2009=\u20090.009) and burning ( p\u2009=\u20090.004). Results of ocular surface staining tests to estimate corneal and conjunctival damage as well as patient satisfaction were also significantly in favour of Homeoptic\u00ae. No new safety concerns were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Homeoptic\u00ae is more effective than Larmabak\u00ae at relieving the symptoms of DED and constitutes an effective treatment for mild-to-moderate DED.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721231216129","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:41:07Z","timestamp":1701996067000},"page":"1119-1127","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Homoeopathic eye drops in the treatment of mild-to-moderate dry eye disease: Randomised, prospective, multicentre, single-masked study"],"prefix":"10.1177","volume":"34","author":[{"given":"B.","family":"Mortemousque","sequence":"first","affiliation":[{"name":"Ophthalmologist, Private practitioner, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PJ.","family":"Pisella","sequence":"additional","affiliation":[{"name":"Ophthalmologist, University Hospital, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Salaun","sequence":"additional","affiliation":[{"name":"Ophthalmologist, Private Practitioner, Jouy aux Arches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Lemaire","sequence":"additional","affiliation":[{"name":"Axonal\/Biostatem, Nanterre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3856-8600","authenticated-orcid":false,"given":"I.","family":"Chanel","sequence":"additional","affiliation":[{"name":"Boiron, Messimy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"bibr1-11206721231216129","first-page":"96","volume":"5","author":"Smith JA","year":"2007","journal-title":"Ocul Surf"},{"key":"bibr2-11206721231216129","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71688-5"},{"key":"bibr3-11206721231216129","first-page":"18","volume":"32","author":"Michaud L","year":"2010","journal-title":"L'Optometriste"},{"key":"bibr4-11206721231216129","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2008.11.001"},{"key":"bibr5-11206721231216129","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2020.1801758"},{"key":"bibr6-11206721231216129","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.07.021"},{"key":"bibr7-11206721231216129","doi-asserted-by":"publisher","DOI":"10.14260\/jemds\/199"},{"key":"bibr8-11206721231216129","volume":"353","author":"Drug and Therapeutics Bulletin Editorial Office","year":"2016","journal-title":"Br Med J"},{"key":"bibr9-11206721231216129","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.9.8.1431"},{"key":"bibr10-11206721231216129","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2013.11.002"},{"key":"bibr11-11206721231216129","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2013.02.002"},{"key":"bibr12-11206721231216129","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2000.6.499"},{"key":"bibr13-11206721231216129","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-0785(05)80288-1"},{"key":"bibr14-11206721231216129","unstructured":"International Academy of Homeopathy. 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