{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:27:27Z","timestamp":1786562847425,"version":"build-2736575974"},"reference-count":49,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Central Serous Chorioretinopathy (CSCR) manifests as fluid accumulation between the neurosensory retina and the retinal pigment epithelium (RPE). Elevated levels of steroid hormones have been implicated in CSCR pathogenesis. This investigation aims to delineate the gene expression patterns of CSCR-associated risk and steroid receptors across human choroidal cell types and RPE cells to discern potential underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study utilized a comprehensive query of transcriptomic data derived from non-pathological human choroid and RPE cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      CSCR-associated genes such as\n                      <jats:italic toggle=\"yes\">PTPRB<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">CFH<\/jats:italic>\n                      , and others are predominantly expressed in the choroidal endothelium as opposed to the RPE. The androgen receptor, encoded by the\n                      <jats:italic toggle=\"yes\">AR<\/jats:italic>\n                      gene, demonstrates heightened expression in the macular endothelium compared to peripheral regions, unlike other steroid receptor genes.\n                      <jats:italic toggle=\"yes\">AR<\/jats:italic>\n                      -expressing endothelial cells display an augmented responsiveness to Transforming growth factor beta (TGF-\u03b2), indicating a propensity towards endothelial to mesenchymal transition (endMT) transcriptional profiling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>These results highlight the proclivity of CSCR to manifest primarily within the choroidal vasculature rather than the RPE, suggesting its categorization as a vascular eye disorder. This study accentuates the pivotal role of androgenic steroids, in addition to glucocorticoids. The observed linkage to TGF-\u03b2-mediated endMT provides a potential mechanistic insight into the disease's etiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721241226735","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T03:14:20Z","timestamp":1706066060000},"page":"1532-1540","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcriptome Analysis of Choroidal Endothelium Links Androgen Receptor Role to Central Serous Chorioretinopathy"],"prefix":"10.1177","volume":"34","author":[{"given":"Sandrine H","family":"K\u00fcnzel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9866-0431","authenticated-orcid":false,"given":"Dominika","family":"Pohlmann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Charit\u00e9 University Hospital Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn zur","family":"Bonsen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Charit\u00e9 University Hospital Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteus","family":"Krappitz","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9 University Hospital Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Zeitz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Charit\u00e9 University Hospital Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia M","family":"Joussen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Charit\u00e9 University Hospital Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Dubrac","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pathologie et Biologie Cellulaire, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen E","family":"K\u00fcnzel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Charit\u00e9 University Hospital Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"D\u00e9partement de Pathologie et Biologie Cellulaire, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2019.07.003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2012.02848.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32981-2"},{"key":"e_1_3_2_5_2","unstructured":"Chorioretinopathia centralis serosa CSS. 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