{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:31:09Z","timestamp":1790101869600,"version":"4.0.1"},"reference-count":37,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the long-term effects of topical latanoprost 0.005% treatment on pupillary functions in early-stage primary open-angle glaucoma (POAG) eyes using automated pupillometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study involved 20 eyes of 20 treatment-naive subjects with early-stage POAG. After comprehensive ophthalmic examination, static and dynamic pupillometry measurements were performedbefore treatment, at the 1st follow-up visit (1.10\u2009\u00b1\u20090.30 months) and the 2nd follow-up visit (25.85\u2009\u00b1\u200910.26 months) after treatment initiation. Dynamic parameters included resting diameter (mm), amplitude (mm), latency (ms), duration (ms), and velocity (mm\/s) of pupil contraction and dilation. Static pupillometry parameters were pupil diameter (PD, mm) in high-photopic, low-photopic, mesopic and scotopic conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The velocity of pupil dilation significantly decreased during the 1st visit (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.008) and the 2nd visit (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.0003) of treatment compared to the pre-treatment visit. The resting PD was also significantly higher after the 1st visit (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.003) and the 2nd visit (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001) compared to the pre-treatment visit. However, the difference in resting PD measured between the 1st and 2nd visits did not reach statistical significance (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.065). There were no significant changes in other dynamic parameters (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.05 for all). Additionally, a mild, but not significant, mydriatic effect was observed in PD measurements under scotopic, mesopic and low photopic lighting conditions after follow-up. None of the static and dynamic parameters correlate with age, changes in intraocular pressure (IOP) or mean deviation (MD) values of visual field tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The long-term topical latanoprost 0.005% treatment in early-stage POAG has a slight mydriatic effect on the pupil. Further longitudinal clinical studies with larger patient cohorts are necessary to better understand the effects of latanoprost on pupillary functions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721241227780","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:18:00Z","timestamp":1705623480000},"page":"1497-1505","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The long-term effects of topical latanoprost 0.005% treatment on pupillary functions: A 2-year longitudinal study"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6521-9984","authenticated-orcid":false,"given":"Serdar","family":"Bayraktar","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3615-8884","authenticated-orcid":false,"given":"G\u00f6zde","family":"Hondur","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Ali","family":"\u015eekero\u011flu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beyhan","family":"Cengiz \u00d6zyurt","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine, Celal Bayar University, Manisa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"\u015een","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3192"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14327"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2012.662219"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-014-9920-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.04.012"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181666557"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2022.1996560"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200308000-00002"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000002212"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003470070087"},{"key":"e_1_3_2_12_2","first-page":"93","article-title":"Effect of topical anti-glaucoma medications on late pupillary light reflex, as evaluated by pupillometry","volume":"29","author":"Ba-Ali S","year":"2015","unstructured":"Ba-Ali S, Sander B, Br\u00f8ndsted AE, et al. 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