{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:11:58Z","timestamp":1787019118906,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,2,4]],"date-time":"2024-02-04T00:00:00Z","timestamp":1707004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>There are no reports in the literature studying the possible relationship between Epstein-Barr virus (EBV) and optic nerve involvement in multiple sclerosis (MS). The aim of our study was to analyze the association between EBV antibodies titres and optical coherence tomography (OCT) and OCT angiography (OCTA) quantitative parameters<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study. The study included 98 eyes of 49 patients with MS. Years of MS duration, relapse count, history of optic neuritis (ON), and immunoglobulin (Ig) G antibodies to the EBV viral capsid antigen (VCA) were recorded from each patient. Also, OCT analysis (including retinal nerve fibre layer (RNFL) thickness and ganglion cell-inner plexiform layer (GCIPL) thickness) and OCTA analysis (including perfusion density (PD) and flux index (FI) of the radial peripapillary capillary plexus) were performed in each participant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant associations were observed between anti-EBV antibody levels and OCT or OCTA parameters (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090,05). Correlation analysis between OCT and OCTA measurements showed a significant positive correlation between RNFL thickness and GCIPL thickness with peripapillary PD and FI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090,035). Subgroup analysis revealed a significant diminution of RNFL thickness, GCIPL thickness and peripapillary PD and FI (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090,05) in the ON group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We were unable to demonstrate a significant association between anti-EBV VCA IgG antibody titres and OCT or OCTA parameters. Nonetheless, further longitudinal studies are needed to explore the possible association of EBV with optic nerve involvement in MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721241230567","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T02:05:20Z","timestamp":1707098720000},"page":"2045-2052","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["New insights in the pathogenic mechanism of multiple sclerosis: Is Epstein-Barr virus associated with optic nerve involvement?"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7919-0462","authenticated-orcid":false,"given":"Lidia","family":"Remol\u00ed-Sargues","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Consorcio Hospital General Universitario of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-0903","authenticated-orcid":false,"given":"Clara","family":"Monferrer-Adsuara","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Consorcio Hospital General Universitario of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"L\u00f3pez-Salvador","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Consorcio Hospital General Universitario of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Garc\u00eda-Villanueva","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Consorcio Hospital General Universitario of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Gracia-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Consorcio Hospital General Universitario of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Castro-Navarro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Consorcio Hospital General Universitario of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Cervera-Taulet","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Consorcio Hospital General Universitario of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,4]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj8222"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.604049"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_431_21"},{"key":"e_1_3_2_5_2","article-title":"Optical coherence tomography angiography in multiple sclerosis: a cross-sectional study","volume":"15","author":"Farci R","unstructured":"Farci R, Carta A, Cocco E, et al. 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