{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:27:32Z","timestamp":1786562852841,"version":"build-2736575974"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the effect of weight reduction on the structural and functional parameters of the optic nerve in established cases of papilledema in Idiopathic Intracranial Hypertension (IIH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective observational study in early and established cases of papilledema in IIH presenting from December 2019 to February 2021. Functional parameters (visual acuity, contrast sensitivity, mean deviation, VER), structural parameters (RNFL, GCL-IPL, and optic disc height), and clinical grading of papilledema were measured at baseline and every 6 weeks for 6 months. All patients underwent medical (oral acetazolamide) and diet therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean body mass index (BMI) at presentation was 26.32\u2009\u00b1\u20093.52\u2005kg\/m\u00b2 and the mean change in BMI over 6 months was 1.27\u2009\u00b1\u20090.50\u2005kg\/m\u00b2. 67% of eyes had papilledema of grades 2\u20133 at the presentation. At the end of 6 months, 75% of eyes had grade 1 papilledema while 13% showed complete resolution. A reduction of 5.32\u2009\u00b1\u20093.58 in mean deviation (r\u2009=\u20090.316; p-value 0.01) and gain in VER P100 amplitude of 4.2\u2009\u00b1\u20092.7\u2005\u00b5V (r\u2009=\u20090.40; p-value 0.003) were noted over 6 months with reduction in BMI over 6 months. A statistically significant reduction in optic disc height (ODH) was noticed with BMI reduction over 6 months (p\u2009=\u20090.0007; r\u2009=\u20090.45).<\/jats:p>\n                    <jats:p>\n                      A reduction of 1.72\u2009\u00b1\u20090.90\u2005kg\/m\u00b2 (\n                      <jats:italic toggle=\"yes\">equivalent to 6.53% weight loss<\/jats:italic>\n                      ) in BMI was associated with a four-grade change in clinical grading of papilledema.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Reduction in BMI had a significant impact on both structural and functional parameters of the optic nerve in IIH. The involvement of a well-certified dietician should be an integral part of treatment in IIH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721241232038","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T08:29:21Z","timestamp":1708504161000},"page":"1594-1599","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of weight reduction on structural and functional parameters of the optic nerve in idiopathic intracranial hypertension"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4346-246X","authenticated-orcid":false,"given":"Mousumi","family":"Banerjee","sequence":"first","affiliation":[{"name":"Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Phuljhele","sequence":"additional","affiliation":[{"name":"Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8660-8062","authenticated-orcid":false,"given":"Rohit","family":"Saxena","sequence":"additional","affiliation":[{"name":"Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Sharma","sequence":"additional","affiliation":[{"name":"Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasundhra","family":"Misra","sequence":"additional","affiliation":[{"name":"Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Vibha","sequence":"additional","affiliation":[{"name":"Department of Neurology, AIIMS, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awadh Kishor","family":"Pandit","sequence":"additional","affiliation":[{"name":"Department of Neurology, AIIMS, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1982.00510200003001"},{"key":"e_1_3_2_3_2","first-page":"155","article-title":"Idiopathic intracranial hypertension: a prospective study of 50 patients","volume":"114","author":"Wall M","year":"1991","unstructured":"Wall M, George D. Idiopathic intracranial hypertension: a prospective study of 50 patients. Brain 1991; 114: 155\u2013180.","journal-title":"Brain"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.7869\/djo.519"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.2.507"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.133"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e31823f852d"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000029570.69134.1B"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6365-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14960"},{"key":"e_1_3_2_11_2","first-page":"163","article-title":"Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management","volume":"57","author":"Misra A","year":"2009","unstructured":"Misra A, Chowbey P. Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management. JAPI 2009; 57: 163\u2013170.","journal-title":"JAPI"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520320065016"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.12.040"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182190f51"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)91234-9"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.5935\/0004-2749.20180006"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.4.1094"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800758"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-7-15"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.06.003"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000448"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721241232038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721241232038","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721241232038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:32:12Z","timestamp":1786559532000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721241232038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,21]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1177\/11206721241232038"],"URL":"https:\/\/doi.org\/10.1177\/11206721241232038","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,21]]}}}