{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:40:29Z","timestamp":1777581629063,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Investigation of pigment epithelial detachment (PED) characteristics in central serous chorioretinopathy (CSCR) is underrepresented in the literature. We present a novel computational approach to quantify PED composition indices (PEDCI) in CSCR and track changes over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>34 eyes with active CSCR were analyzed quarterly over a 1-year period. Cases were categorized into acute and chronic CSCR depending on a symptom duration of less than 3 months or more than 3 months respectively. PED, retinal and choroidal dimensions were manually measured, and interval changes were compared using repeated measures of variance ANOVA. PED composition analysis involved manual segmentation followed by automated sub segmentation of PED areas to identify serous, neovascular and fibrous tissues. PEDCI for each component was compared among cases of acute and chronic CSCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CMT and NSD-h decreased by 65.2\u2005\u00b5m (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), and 86.5\u2005\u00b5m (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) respectively at 12 months. At baseline, 7\/17 acute CSCR eyes and 8\/15 chronic CSCR eyes had a concomitant PED; acute cases had both serous and neovascular components (PEDCI-S: 16.95%, PEDCI-N: 40.3%), whereas chronic cases only had a neovascular component (PEDCI-S: 0%, PEDCI-N: 30.5%). At 12-month follow-up, 6\/7 of acute CSCR group and 6\/8 chronic CSCR group had a concomitant PED; PEDCI-S was largest for acute CSCR (53.4%) and PEDCI-N was largest for chronic CSCR (46.7%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We identify a novel biomarker PEDCI to differentiate acute and chronic CSCR with higher PEDCI-S in acute CSCR, and higher PEDCI-N in chronic CSCR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721241235052","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T02:08:21Z","timestamp":1708999701000},"page":"1991-1997","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Pigment epithelial detachment composition indices in central serous chorioretinopathy as a biomarker for disease activity: A computational methodology and 1 year outcomes"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1894-7772","authenticated-orcid":false,"given":"Sanya","family":"Yadav","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6890-6633","authenticated-orcid":false,"given":"Arman","family":"Zarnegar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Driban","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrish","family":"Selvam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supriya","family":"Arora","sequence":"additional","affiliation":[{"name":"Bahamas Vision Center and Princess Margaret Hospital, Nassau, NP, Bahamas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumit Randhir","family":"Singh","sequence":"additional","affiliation":[{"name":"Nilima Sinha Medical College and Hospital, Madhepura, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-5343","authenticated-orcid":false,"given":"Jay","family":"Chhablani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.01.021"},{"key":"e_1_3_2_3_2","first-page":"1","article-title":"Pathogenesis of disciform detachment of the neuroepithelium","volume":"63","author":"Gass JD","year":"1967","unstructured":"Gass JD. Pathogenesis of disciform detachment of the neuroepithelium. Am J Ophthalmol 1967; 63: 1\u2013139.","journal-title":"Am J Ophthalmol"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08550-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090200063023"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000742"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002051"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_2092_18"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001580"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1120672120904670"},{"key":"e_1_3_2_11_2","first-page":"20201016","article-title":"Current choroidal imaging findings in central serous chorioretinopathy","volume":"4","author":"Nkrumah G","year":"2020","unstructured":"Nkrumah G, Maltsev DS, Manuel PA, et al. Current choroidal imaging findings in central serous chorioretinopathy. Vision (Basel) 2020; 4:20201016. doi:https:\/\/doi.org\/10.3390\/vision4040044","journal-title":"Vision (Basel)"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_3401_20"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_809_21"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","unstructured":"Selvam A Singh SR and Arora S. Pigment epithelial detachment composition indices (PEDCI) in neovascular age-related macular degeneration. 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