{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:41:12Z","timestamp":1777581672881,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate outcomes after Brolucizumab injection in na\u00efve treatment or non-responder patients with exudative age-related macular degeneration (AMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>It is a retrospective, comparative, cohort study conducted at the tertiary referral center of the University Hospital Polyclinic of Bari, for 5 years, from November 2017 until May 2022. 41 eyes with wet-AMD (w-AMD) were included, undergoing anti-vascular endothelial growth factor (VEGF) intravitreal injections. The sample was divided into two groups, the Bro-Switch group, and the Bro-Na\u00efve group. The Bro-Switch group previously received a slot of other anti-VEGF intravitreal drugs. The Bro-Na\u00efve group received Brolucizumab (Bro) as the first treatment. The pigment epithelium detachment (PED) and the best-corrected visual acuity (BCVA) outcomes before and after Bro-injection were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant reduction in PED measurement was registered in all eyes treated with Bro-injection (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.35). The Bro-Na\u00efve group improved better in PED measurement (mean difference: 297.92\u2009\u00b1\u200972,32) as compared to the Bro-Switch group (mean difference: 185.06\u2009\u00b1\u200911.07). On the contrary, no significant reduction in BCVA in the two groups was recorded (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.66).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We suggest Bro-injection for w-AMD as effective anatomical outcomes in PED flattening, but not similar in visual results. Although this study evaluated short-term outcomes, the hopeful results can lead to interesting medium-long time effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721241238391","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T03:29:25Z","timestamp":1710127765000},"page":"2025-2031","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Brolucizumab effectiveness in pigment epithelium detachment due to exudative AMD in na\u00efve treatment or non-responder patients"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0254-7432","authenticated-orcid":false,"given":"Claudio","family":"Furino","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Neurology and Sensory Organs, Eye Clinic, Bari University, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6193-3299","authenticated-orcid":false,"given":"Valeria","family":"Albano","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Neurology and Sensory Organs, Eye Clinic, Bari University, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"D\u2019Addario","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Neurology and Sensory Organs, Eye Clinic, Bari University, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Reibaldi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Eye Clinic, Turin University, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Boscia","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Neurology and Sensory Organs, Eye Clinic, Bari University, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Alessio","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Neurology and Sensory Organs, Eye Clinic, Bari University, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"353","article-title":"Age-related macular degeneration (AMD): pathogenesis and therapy","volume":"58","author":"Nowak JZ","unstructured":"Nowak JZ. 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