{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:42:04Z","timestamp":1777581724521,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Glaucoma is the second-leading cause of blindness in the US for people over the age of 40; the most common form is primary open-angle glaucoma (POAG). It has been suggested that inflammatory markers have a role in the development and the progression of glaucoma (GL). High-sensitivity C reactive protein (HsCRP) is an inflammatory marker that has been linked to cardiovascular disease and a possible link to GL. Although a number of studies have found a link between CRP and GL; POAG, normal tension glaucoma (NTG), exfoliation glaucoma (XFG), Exfoliation syndrome (XFS), other research has shown the opposite.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This systematic review is to determine the association between HsCRP and GL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>A literature search was conducted using the MEDLINE database. We identified thirty-six peer-reviewed studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five retrospective studies were included and summed up to 164305 study participants, 161759 POAG patients, and 2546 controls. The pooled result of all studies revealed that HsCRP (SMD: 0.44 mg\/dl; [95% confidence interval \u22120.10 to 0.99]; P\u2009=\u20090.11, I\n                      <jats:sup>2<\/jats:sup>\n                      89%) concentration was not significantly higher in POAG patients compared to the healthy controls. The SMD for NTG, XFG and XFS; 0.64 mg\/dl; 0.03 mg\/dl, 0.03 mg\/dl respectively. The pooled result revealed that HsCRP concentration was not significantly higher in POAG, NTG, XFG, and XFS. No publication bias was found using the funnel plot.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The meta-analysis concluded that there is no correlation between the elevated plasma levels of HsCRP and GL. Future studies should be conducted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721241248019","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T01:34:27Z","timestamp":1715823267000},"page":"29-39","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A meta-analysis of the association between high-sensitivity c-reactive protein level and glaucoma"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5253-1175","authenticated-orcid":false,"given":"Mashael","family":"Al-Namaeh","sequence":"first","affiliation":[{"name":"Clinical Virtual Research Center, Wayne, PA, USA"},{"name":"Kentucky College of Optometry, University of Pikeville, Pikeville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"bibr1-11206721241248019","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7277.4"},{"key":"bibr2-11206721241248019","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318921"},{"key":"bibr3-11206721241248019","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00008-3"},{"key":"bibr4-11206721241248019","doi-asserted-by":"publisher","DOI":"10.1159\/000006953"},{"key":"bibr5-11206721241248019","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(00)00196-X"},{"key":"bibr6-11206721241248019","doi-asserted-by":"publisher","DOI":"10.4103\/0974-9233.75882"},{"key":"bibr7-11206721241248019","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0024"},{"key":"bibr8-11206721241248019","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.10.026"},{"key":"bibr9-11206721241248019","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9123838"},{"key":"bibr10-11206721241248019","doi-asserted-by":"publisher","DOI":"10.1097\/01.ijg.0000176932.06606.6e"},{"key":"bibr11-11206721241248019","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2012.725798"},{"key":"bibr12-11206721241248019","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3180391a83"},{"key":"bibr13-11206721241248019","unstructured":"Wells G, Shea B, O'Connell D, et al. 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