{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:42:16Z","timestamp":1777581736765,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report a very rare and atypical case of an elderly Caucasian female patient who developed perilesional multiple polypoidal choroidal vasculopathy (PCV) as a probable complication of choroidal osteoma (CO), associated to preretinal neovascular membrane overlying the lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observational case report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case observation<\/jats:title>\n                    <jats:p>A 60-year-old Caucasian woman presented with blurred vision in her right eye (RE). Fundus examination revealed a round white-yellowish calcified deep lesion in the juxta-papillary superior area, measuring 4 disc-diameters, with well-defined scalloped margins and an irregular surface. B-scan ultrasonography and orbital tomography confirmed the diagnosis of choroidal osteoma (CO). Further investigation with multimodal imaging including infracyanine green angiography, fluorescein angiography, swept source optical coherence tomography and angiography highlighted the presence of multiple aneurysmal choroidal dilations around the CO, corresponding to PCV. We also noted the presence of a preretinal neovascular membrane overlying the CO. The patient was monitored with regular follow-up since no signs of activity were detected on multimodal imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our case report represents an exceptional and atypical association between pre-retinal neovascularization, PCV and choroidal osteoma. While the mechanisms underlying the development of PCV and pre-retinal neovascularization in the setting of CO are not well understood, it is imperative for ophthalmologists to recognize this association as a potential cause of sudden vision loss in patients with CO, and to consider appropriate diagnostic and management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721241249218","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T03:49:05Z","timestamp":1713757745000},"page":"NP58-NP63","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Atypical case of choroidal osteoma associated to polypoidal choroidal vasculopathy and preretinal neovascular membrane"],"prefix":"10.1177","volume":"34","author":[{"given":"Mohamed","family":"Ben Brahem","sequence":"first","affiliation":[{"name":"Department of ophthalmology A, Institut H\u00e9di Raies d\u2019ophtalmologie de Tunis, Tunis, Tunisia"},{"name":"Facult\u00e9 de m\u00e9decine de Tunis, Universit\u00e9 Tunis - El Manar, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"EL MATRI","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine de Tunis, Universit\u00e9 Tunis - El Manar, Tunis, Tunisia"},{"name":"Department of ophthalmology B, Institut H\u00e9di Raies d\u2019ophtalmologie de Tunis, Tunis, Tunisia"},{"name":"Oculogenetic laboratory LR14SP01, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousra","family":"Fafloul","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine de Tunis, Universit\u00e9 Tunis - El Manar, Tunis, Tunisia"},{"name":"Department of ophthalmology B, Institut H\u00e9di Raies d\u2019ophtalmologie de Tunis, Tunis, Tunisia"},{"name":"Oculogenetic laboratory LR14SP01, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel","family":"Chebbi","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine de Tunis, Universit\u00e9 Tunis - 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