{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:42:35Z","timestamp":1777581755282,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002535."],"award-info":[{"award-number":["UL1 TR002535."]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To quantify and compare the different prevalence rates of specific retinal imaging biomarkers in patients with intermediate AMD (iAMD) and advanced non-neovascular AMD (nnAMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross-sectional study of patients with iAMD and advanced nnAMD. Imaging studies were reviewed for qualitative imaging biomarkers. Choroidal thickness measurements were obtained subfoveally and in 1000\u2005um and 2000\u2005um intervals away from the fovea. The Chi-squared test and Fisher's exact test were used to compare rates of imaging biomarkers among the two cohorts. P-value of &lt;0.05 was considered significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>376 eyes of 197 patients with iAMD and 187 eyes of 97 patients with advanced nnAMD were recruited. There were significantly lower rates of the following imaging biomarkers in the iAMD compared with the advanced nnAMD cohorts: soft drusen (66.0% vs. 84.2%, p\u2009=\u20090.001), calcified drusen (4.3% vs. 40.0%, p\u2009&lt;\u20090.0001), RPD (26.2% vs. 53.3%, p\u2009&lt;\u20090.0001), ORT (0.5% vs. 46.9%, p\u2009&lt;\u20090.0001), RP (1.1% vs. 46.3%, p\u2009&lt;\u20090.0001), pigment migration (53.2% vs. 100%, p\u2009&lt;\u20090.0001), and iRORA (17.9% vs. 80.2%, p\u2009&lt;\u20090.0001). In the iAMD cohort, choroidal thickness was significantly greater at 188\u2005\u00b5m (SD: 60) and 194\u2005\u00b5m (SD: 69), compared to the advanced nnAMD with measurements of 153\u2005\u00b5m (SD: 68), and 161\u2005\u00b5m (SD: 76). This difference was statistically significant ( p\u2009&lt;\u20090.0001 and p\u2009=\u20090.0002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results highlight significant differences in imaging biomarkers between both cohorts. Key biomarkers, such as iRORA, RPD, pigment migration, and thinner choroidal thickness, were associated with advanced nnAMD. Identifying these biomarkers early may help target patients who could benefit from new treatments, potentially delaying vision loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721241255156","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:53:17Z","timestamp":1715302397000},"page":"276-282","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Differences in imaging biomarkers between patients with intermediate and advanced non-neovascular age-related macular degeneration (AMD) in the University of Colorado AMD registry"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-0116","authenticated-orcid":false,"given":"Andres","family":"Lisker-Cervantes","sequence":"first","affiliation":[{"name":"Sue Anschutz-Rodgers Eye Center, University of Colorado Anschutz Medical Campus, Aurora, CO, 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