{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:14:15Z","timestamp":1790727255142,"version":"4.1.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T00:00:00Z","timestamp":1716595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005809","name":"Hyderabad Eye Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To describe the clinical and imaging features of circumscribed choroidal hemangiomas (CCH) and their treatment outcomes with Ruthenium-106 (\n                      <jats:sup>106<\/jats:sup>\n                      Ru) plaque brachytherapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective study of 24 patients (24 eyes) diagnosed with CCH and treated with\n                      <jats:sup>106<\/jats:sup>\n                      Ru plaque between 2017 and 2022. Analysis included pre- and post-treatment clinical and imaging features such as tumor regression, reduction in height, subretinal fluid (SRF) resolution, and change in best-corrected visual acuity (BCVA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age at presentation was 36 years (range, 16\u201357). The most common tumor location was the temporal quadrant ( n\u2009=\u200919) with macular involvement ( n\u2009=\u200913). Associated features were macular SRF ( n\u2009=\u200922) and inferior exudative retinal detachment ( n\u2009=\u200910). Nineteen of the 24 patients underwent primary treatment, whereas 5 patients underwent plaque as a salvage treatment. The mean tumor apex dose was 40 Gy. At a median follow-up of 7.5 months (range 3\u201365 months), 18 eyes showed complete regression, whereas 6 eyes showed partial regression. The mean height decreased from 4.8 (SD 1.28) mm at presentation to 2.5 (SD 1.63) mm. Median BCVA improved from logMAR 1.2 (IQR 0.4\u20132) at baseline to logMAR 1.05 (IQR 0.1\u20131.95) ( p\u2009=\u20090.4). Complete resolution of the macula and tumor SRF was observed in 15 (68%) and 13 (57%) eyes, respectively. The radiation-related complications observed were radiation maculopathy (4 eyes), retinopathy (1 eye), and vitreous hemorrhage (1 eye).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ruthenium-106 plaque brachytherapy is effective for CCH (&gt; 3 mm height) as a primary and salvage treatment for tumors unresponsive to other modalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721241257974","type":"journal-article","created":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T04:02:56Z","timestamp":1716609776000},"page":"367-374","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Ruthenium-106 (\n                    <sup>106<\/sup>\n                    Ru) plaque brachytherapy for treatment of circumscribed choroidal hemangioma"],"prefix":"10.1177","volume":"35","author":[{"given":"Vidhi","family":"Bajpai","sequence":"first","affiliation":[{"name":"Anand Bajaj Retina Institute, L.V. Prasad Eye Institute, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8446-2696","authenticated-orcid":false,"given":"Vishal","family":"Raval","sequence":"additional","affiliation":[{"name":"Anand Bajaj Retina Institute, L.V. Prasad Eye Institute, Hyderabad, India"},{"name":"The Operation Eyesight Universal Institute for Eye Cancer, L.V. Prasad Eye Institute, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay Anand","family":"Reddy P","sequence":"additional","affiliation":[{"name":"The Operation Eyesight Universal Institute for Eye Cancer, L.V. Prasad Eye Institute, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0800-9961","authenticated-orcid":false,"given":"Swathi","family":"Kaliki","sequence":"additional","affiliation":[{"name":"The Operation Eyesight Universal Institute for Eye Cancer, L.V. 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