{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T14:30:41Z","timestamp":1783175441168,"version":"3.54.6"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the impact of multiple medications on the quality of life of primary open angle glaucoma (POAG) patients on medical treatment at Guinness Eye Centre Onitsha, Nigeria<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Adult patients diagnosed with POAG who were undergoing medical therapy were selected through systematic sampling. They were asked to provide information on socio-demographic background, the number and types of glaucoma medications they were using and any adverse effects encountered while using these medications. The patients\u2019 quality of life was assessed by utilizing the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25) and all patients completed ocular examination. Data analysis was with Statistical Package for Social Sciences (SPSS) version 23.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred and seventy-one patients, aged 40\u201383 years, mean 59.1\u2009\u00b1\u200911.1 were studied; there were 79(46.2%) males and 92(53.8%) females. One hundred and nine (63.7%) patients were on multiple medications. Side effects of treatment increased with increasing number of medications. The mean quality of life score in monotherapy group and double therapy group were 89.3\u2009\u00b1\u200915.8 and 80.2\u2009\u00b1\u200921.1 respectively; while that in\u2009\u2265\u2009triple therapy group was 78.9\u2009\u00b1\u200918.8. This decrease in mean quality of life score with increasing number of medications was statistically significant in bivariate analysis ( P\u2009&lt;\u20090.01), however, multiple regression analysis showed that the number of medications did not significantly affect the quality of life scores after adjusting for confounding variables( p\u2009=\u20090.881).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among the patients studied, use of multiple medications, unlike visual acuity (VA) and severity of glaucoma, was not an independent predictor of quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721241272179","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T06:20:02Z","timestamp":1722925202000},"page":"576-581","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Multiple medications and quality of life of Nigerians with primary open angle glaucoma"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0240-9689","authenticated-orcid":false,"given":"Chinasa Anderline","family":"Nnubia","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Nnamdi Azikiwe University Teaching Hospital, Guinness Eye Centre, Onitsha, Anambra State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian Ndulue Ntuko","family":"Nwosu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nnamdi Azikiwe University Teaching Hospital, Guinness Eye Centre, Onitsha, Anambra State, Nigeria"},{"name":"Department of Ophthalmology, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nonso Ejikeme","family":"Okpala","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nnamdi Azikiwe University Teaching Hospital, Guinness Eye Centre, Onitsha, Anambra State, Nigeria"},{"name":"Department of Ophthalmology, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akunne Ijeoma","family":"Apakama","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nnamdi Azikiwe University Teaching Hospital, Guinness Eye Centre, Onitsha, Anambra State, Nigeria"},{"name":"Department of Ophthalmology, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeanyi James","family":"Orji","sequence":"additional","affiliation":[{"name":"Department of Surgery, Federal Medical Centre Umuahia, Abia State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chizoba Udoka","family":"Uba-Obiano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nnamdi Azikiwe University Teaching Hospital, Guinness Eye Centre, Onitsha, Anambra State, Nigeria"},{"name":"Department of Ophthalmology, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adaora Amaoge","family":"Onyiaorah","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nnamdi Azikiwe University Teaching Hospital, Guinness Eye Centre, Onitsha, Anambra State, Nigeria"},{"name":"Department of Ophthalmology, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"bibr1-11206721241272179","unstructured":"Basic and Clinical Science Course. 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