{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:44:18Z","timestamp":1777581858125,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to compare the effect of intravitreal aflibercept (IVA) and ranibizumab (IVR) on the maximal diameter of the largest intraretinal cyst (mdIRC), indicating chronicity in patients with diabetic cystoid macular edema (CME).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, comparative study included a subgroup of patients from the MARMASIA Study with treatment-na\u00efve diabetic CME who had IVA (IVA group) or IVR (IVR group) on a pro re nata regimen after a loading dose of 3-monthly injections and followed-up for 24 months. Best-corrected visual acuity (logMAR), central macular thickness (CMT, \u00b5m), and mdIRC (\u00b5m) and their changes during the study period in the IVA and IVR groups were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 175 eyes (65 [37.1%] in IVA and 110 [62.9%] in IVR group) of 113 patients were included in the study analysis. Both groups had statistically significant improvements in BCVA and CMT during the follow-up (p\u2009&lt;\u20090.05 for all), which were comparable between the groups at each time point. However, the mean reduction in mdIRCs was consistently and significantly higher in the IVA group compared to the IVR group at each follow-up examination (F[1, 3.52]\u2009=\u20096.93, p\u2009=\u20090.009).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IVA seems to have a greater impact in reducing cyst sizes than IVR in diabetic CME.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/11206721241280737","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T00:31:09Z","timestamp":1725669069000},"page":"980-989","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of ranibizumab and aflibercept on reducing maximum diameter of largest cyst in diabetic cystoid macular edema: MARMASIA study group"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6260-6716","authenticated-orcid":false,"given":"Ecem \u00d6nder","family":"Toku\u00e7","sequence":"first","affiliation":[{"name":"Kocaeli University School of Medicine, Department of Ophthalmology, Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7860-4603","authenticated-orcid":false,"given":"V. Levent","family":"Karaba\u015f","sequence":"additional","affiliation":[{"name":"Kocaeli University School of Medicine, Department of Ophthalmology, Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7130-4798","authenticated-orcid":false,"given":"Mehmet Orkun","family":"Sevik","sequence":"additional","affiliation":[{"name":"Marmara University School of Medicine, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih Bilgehan","family":"Kaplan","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7367-2906","authenticated-orcid":false,"given":"I\u015f\u0131l","family":"Kutlut\u00fcrk Karag\u00f6z","sequence":"additional","affiliation":[{"name":"Istanbul Beyo\u011flu Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice Selen","family":"Kanar","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Kartal Dr. L\u00fctfi K\u0131rdar City Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U\u011fur","family":"Yayla","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Derince Training and Research Hospital, Department of Ophthalmology, Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0523-5979","authenticated-orcid":false,"given":"Ay\u015fe Demirciler","family":"S\u00f6nmez","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5426-1992","authenticated-orcid":false,"given":"Aslan","family":"Aykut","sequence":"additional","affiliation":[{"name":"Marmara University School of Medicine, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4998-1896","authenticated-orcid":false,"given":"Utku","family":"Limon","sequence":"additional","affiliation":[{"name":"University of Health Sciences, \u00dcmraniye Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5570-799X","authenticated-orcid":false,"given":"Erdin\u00e7","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"University of Health Sciences, \u00dcmraniye Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u015f\u0131lay","family":"\u00d6zsoy Sayg\u0131n","sequence":"additional","affiliation":[{"name":"University of Health Sciences, \u00dcmraniye Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2624-7496","authenticated-orcid":false,"given":"Tu\u011fba","family":"Aydo\u011fan Gezginaslan","sequence":"additional","affiliation":[{"name":"University of Health Sciences, \u00dcmraniye Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimet Ye\u015fim","family":"Er\u00e7al\u0131k","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Haydarpa\u015fa Numune Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6285-6566","authenticated-orcid":false,"given":"Esra","family":"Kumral T\u00fcrkseven","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Haydarpa\u015fa Numune Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zlem","family":"Ayd\u0131n \u00d6nc\u00fc","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Haydarpa\u015fa Numune Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkan","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Sakarya University School of Medicine, Department of Ophthalmology, Sakarya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ece","family":"Ba\u015faran Emengen","sequence":"additional","affiliation":[{"name":"Kocaeli University School of Medicine, Department of Ophthalmology, Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"\u00d6zkaya","sequence":"additional","affiliation":[{"name":"Memorial \u015ei\u015fli Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu A\u00e7\u0131kal\u0131n","family":"\u00d6ncel","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nursal Melda","family":"Yenerel","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Haydarpa\u015fa Numune Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zlem","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Marmara University School of Medicine, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"The efficacy and safety of current treatments in diabetic macular edema: a systematic review and network meta-analysis","volume":"11","author":"Zhang L","year":"2016","unstructured":"Zhang L, Wang W, Gao Y, et al. The efficacy and safety of current treatments in diabetic macular edema: a systematic review and network meta-analysis. PLoS One 2016; 11: e0159553.","journal-title":"PLoS One"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3701-4-27"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.03.024"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2008.10.001"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.6565"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.1669"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.05.015"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001038"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.12.039"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.4274\/tjo.galenos.2023.56249"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1120672119880394"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001459"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8644"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414264"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.02.022"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.03.021"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000081203"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000360463"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14137"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(84)90233-9"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.08.022"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.02.036"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3828-1"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4493"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318285cc52"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S303670"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2021.1889620"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-015-0081-7"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S316271"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1348855"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721241280737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11206721241280737","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11206721241280737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:46:46Z","timestamp":1777405606000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11206721241280737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,5]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/11206721241280737"],"URL":"https:\/\/doi.org\/10.1177\/11206721241280737","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,5]]}}}